2-Hydroxycyclohexanethiol

Base Information

• Chemical Name: 2-Hydroxycyclohexanethiol
• CAS No.: 16166-53-3
• Molecular Formula: C₆H₁₂OS
• Molecular Weight: 132.227
• Mol file: 16166-53-3.mol

Synonyms:2-Hydroxycyclohexanethiol

Chemical Property of 2-Hydroxycyclohexanethiol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-Hydroxycyclohexanethiol

There total 15 articles about 2-Hydroxycyclohexanethiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

cyclohexane-1,2-epoxide (286-20-4) → (+/-)-trans-1-mercaptocyclohexan-2-ol (16166-53-3,56155-48-7,60861-06-5,68972-89-4)

Guidance literature:

With hydrosulfide exchange resin (from Amberlite IRA-400); triethylamine hydrochloride; In methanol; at 50 ℃; for 3h;

DOI:10.1055/s-1995-3929

Reference yield: 90.0%

hexamethyldisilathiane (3385-94-2) + cyclohexane-1,2-epoxide (286-20-4) → (+/-)-trans-1-mercaptocyclohexan-2-ol (16166-53-3,56155-48-7,60861-06-5,68972-89-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

DOI:10.1055/s-2005-921922

Reference yield: 90.0%

C12H22O2S2 → (+/-)-trans-1-mercaptocyclohexan-2-ol (16166-53-3,56155-48-7,60861-06-5,68972-89-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 3h;

DOI:10.1016/S0957-4166(99)00446-2

upstream raw materials:

cyclohexane-1,2-epoxide

hexamethyldisilathiane

cyclohexene oxide

cyclohexanone

Downstream raw materials:

(+/-)-trans-1-acetoxy-2-acetylsulfanyl-cyclohexane

trans-2-ethylsulfanyl-cyclohexanol

cyclohexene sulfide

7-thiabicyclo[4.1.0]heptane

Refernces

• 1、 Justo De Pomar, Jorge C.,Soderquist, John A.. "Regio- and stereospecific synthesis of (O-tips)-protected 2- hydroxyalkylmercaptans from epoxides and triisopropylsilanethiol". . p. 4409 - 4412. Retrieved 1998.
• 2、 -. "PEPTIDE CONJUGATES OF CYTOTOXINS AS THERAPEUTICS". . . Retrieved 2021/01/25.
• 3、 Poladura, Belén,Martínez-Casta?eda, ángel,Rodríguez-Solla, Humberto,Concellón, Carmen,Del Amo, Vicente. "TBD-catalyzed α-sulfenylation of cyclic ketones: Desymmetrization of 4-substituted cyclohexanones". . p. 6438 - 6446. Retrieved 2012/08/28.