N-(4-{(Z)-2-fluoro-2-[5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]vinyl}benzyl)-N-isopropylpropane-2-amine

Base Information

Chemical Name:N-(4-{(Z)-2-fluoro-2-[5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]vinyl}benzyl)-N-isopropylpropane-2-amine
CAS No.:1418297-24-1
Molecular Formula:C₂₄H₃₄FN₃O
Molecular Weight:399.552
Hs Code.:

Synonyms:N-(4-{(Z)-2-fluoro-2-[5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]vinyl}benzyl)-N-isopropylpropane-2-amine

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Chemical Property of N-(4-{(Z)-2-fluoro-2-[5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]vinyl}benzyl)-N-isopropylpropane-2-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(4-{(Z)-2-fluoro-2-[5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]vinyl}benzyl)-N-isopropylpropane-2-amine

There total 9 articles about N-(4-{(Z)-2-fluoro-2-[5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]vinyl}benzyl)-N-isopropylpropane-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1418297-23-0
3-{(Z)-2-[4-(bromomethyl)phenyl]-1-fluorovinyl}-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole

: 108-18-9
diisopropylamine

: 1418297-24-1
N-(4-{(Z)-2-fluoro-2-[5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]vinyl}benzyl)-N-isopropylpropane-2-amine

Guidance literature:: In toluene; at 150 ℃; for 1h; Microwave irradiation;

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1418297-24-1
N-(4-{(Z)-2-fluoro-2-[5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]vinyl}benzyl)-N-isopropylpropane-2-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 16 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

4.1: N,N-dimethyl-formamide / 1 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

6.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

6.2: 16 h / -78 - 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

8.1: toluene / 1 h / 150 °C / Microwave irradiation

With toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 4027-57-0
ethyl 5-methyl-1H-pyrazole-3-carboxylate

: 1418297-24-1
N-(4-{(Z)-2-fluoro-2-[5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]vinyl}benzyl)-N-isopropylpropane-2-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 16 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

4.1: N,N-dimethyl-formamide / 1 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

6.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

6.2: 16 h / -78 - 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

8.1: toluene / 1 h / 150 °C / Microwave irradiation

With toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;