(1S,2R,3S,4R)-Bicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester

Base Information

Chemical Name:(1S,2R,3S,4R)-Bicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester
CAS No.:162361-99-1
Molecular Formula:C₂₆H₃₄O₄
Molecular Weight:410.554
Hs Code.:

Synonyms:(1S,2R,3S,4R)-Bicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester

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Chemical Property of (1S,2R,3S,4R)-Bicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester

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Technology Process of (1S,2R,3S,4R)-Bicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester

There total 3 articles about (1S,2R,3S,4R)-Bicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1165952-91-9
cyclohexa-1,3-diene

: 162361-93-5
tert-butyl (1R,2S)-2-phenylcyclohexyl maleate

: 162361-99-1
(1S,2R,3S,4R)-Bicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester

Guidance literature:: With diethylaluminium chloride; In dichloromethane; at -40 ℃; for 5.5h;
DOI:10.1021/ja00093a013

Reference yield:

: 98919-68-7
(1R,2S)-trans-2-phenylcyclohexanol

: 162361-99-1
(1S,2R,3S,4R)-Bicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / Heating

2: conc. H₂SO₄ / CH₂Cl₂ / Ambient temperature

3: 98 percent / Et₂AlCl / CH₂Cl₂ / 5.5 h / -40 °C

With sulfuric acid; diethylaluminium chloride; In dichloromethane; toluene;
DOI:10.1021/ja00093a013

Reference yield:

: (Z)-But-2-enedioic acid mono-((1R,2S)-2-phenyl-cyclohexyl) ester

: 162361-99-1
(1S,2R,3S,4R)-Bicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: conc. H₂SO₄ / CH₂Cl₂ / Ambient temperature

2: 98 percent / Et₂AlCl / CH₂Cl₂ / 5.5 h / -40 °C

With sulfuric acid; diethylaluminium chloride; In dichloromethane;
DOI:10.1021/ja00093a013