<1-(4-ethylphenyl)-2-<2-nitro-6-(trifluoromethyl)phenyl>ethyl>propanedioic acid, dimethyl ester

Base Information

Chemical Name:<1-(4-ethylphenyl)-2-<2-nitro-6-(trifluoromethyl)phenyl>ethyl>propanedioic acid, dimethyl ester
CAS No.:138384-05-1
Molecular Formula:C₂₂H₂₂F₃NO₆
Molecular Weight:453.415
Hs Code.:

Synonyms:<1-(4-ethylphenyl)-2-<2-nitro-6-(trifluoromethyl)phenyl>ethyl>propanedioic acid, dimethyl ester

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Chemical Property of <1-(4-ethylphenyl)-2-<2-nitro-6-(trifluoromethyl)phenyl>ethyl>propanedioic acid, dimethyl ester

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Technology Process of <1-(4-ethylphenyl)-2-<2-nitro-6-(trifluoromethyl)phenyl>ethyl>propanedioic acid, dimethyl ester

There total 1 articles about <1-(4-ethylphenyl)-2-<2-nitro-6-(trifluoromethyl)phenyl>ethyl>propanedioic acid, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 6656-49-1
2-methyl-1-nitro-3-(trifluoromethyl)benzene

: 138334-75-5
2-(4-Ethyl-benzylidene)-malonic acid dimethyl ester

: 138384-05-1
<1-(4-ethylphenyl)-2-<2-nitro-6-(trifluoromethyl)phenyl>ethyl>propanedioic acid, dimethyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 5h;
DOI:10.1021/jm00082a020

Reference yield:

: 138384-05-1
<1-(4-ethylphenyl)-2-<2-nitro-6-(trifluoromethyl)phenyl>ethyl>propanedioic acid, dimethyl ester

: 138335-13-4
(3S,4R)-4-(4-Ethyl-phenyl)-3-methyl-6-trifluoromethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 20 min, 2.) DMF, 0 deg C, 4 h

2: 92 percent / H₂ / 10percent Pd/C / acetonitrile / 4 h / 2068.6 Torr

3: 75 percent / MeONa / methanol / 3 h / Heating

4: LiBr / dimethylformamide / 4 h / Heating

With hydrogen; sodium methylate; sodium hydride; lithium bromide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00082a020

Reference yield:

: 138384-05-1
<1-(4-ethylphenyl)-2-<2-nitro-6-(trifluoromethyl)phenyl>ethyl>propanedioic acid, dimethyl ester

: 138335-13-4
cis-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-methyl-4-(4-ethylphenyl)-2H-1-benzazepin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 20 min, 2.) DMF, 0 deg C, 4 h

2: 92 percent / H₂ / 10percent Pd/C / acetonitrile / 4 h / 2068.6 Torr

3: 75 percent / MeONa / methanol / 3 h / Heating

4: LiBr / dimethylformamide / 4 h / Heating

With hydrogen; sodium methylate; sodium hydride; lithium bromide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00082a020