3-chloro-5-((6-oxo-1-((6-oxo-5-phenyl-1,6-dihydropyridazin-3-yl)methyl)-4-(trifluoro methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Base Information

Chemical Name:3-chloro-5-((6-oxo-1-((6-oxo-5-phenyl-1,6-dihydropyridazin-3-yl)methyl)-4-(trifluoro methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile
CAS No.:1591824-21-3
Molecular Formula:C₂₃H₁₃ClF₃N₅O₃
Molecular Weight:499.836
Hs Code.:

Synonyms:3-chloro-5-((6-oxo-1-((6-oxo-5-phenyl-1,6-dihydropyridazin-3-yl)methyl)-4-(trifluoro methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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Chemical Property of 3-chloro-5-((6-oxo-1-((6-oxo-5-phenyl-1,6-dihydropyridazin-3-yl)methyl)-4-(trifluoro methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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Technology Process of 3-chloro-5-((6-oxo-1-((6-oxo-5-phenyl-1,6-dihydropyridazin-3-yl)methyl)-4-(trifluoro methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

There total 14 articles about 3-chloro-5-((6-oxo-1-((6-oxo-5-phenyl-1,6-dihydropyridazin-3-yl)methyl)-4-(trifluoro methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1591827-43-8
3-chloro-5-((1-((1-(4-methoxybenzyl)-6-oxo-5-phenyl-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

: 1591824-21-3
3-chloro-5-((6-oxo-1-((6-oxo-5-phenyl-1,6-dihydropyridazin-3-yl)methyl)-4-(trifluoro methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: In trifluoroacetic acid; trifluoroacetic anhydride;

Reference yield:

: 63001-30-9
methyl 6‐oxo‐1,6‐dihydropyridazine‐3‐carboxylate

: 1591824-21-3
3-chloro-5-((6-oxo-1-((6-oxo-5-phenyl-1,6-dihydropyridazin-3-yl)methyl)-4-(trifluoro methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: bromine

2: potassium carbonate / N,N-dimethyl-formamide

3: sodium tetrahydroborate / tetrahydrofuran; methanol

4: tetrahydrofuran

5: triethylamine / N,N-dimethyl-formamide

6: potassium phosphate / water

7: trifluoroacetic acid; trifluoroacetic anhydride

With sodium tetrahydroborate; potassium phosphate; bromine; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; trifluoroacetic acid; trifluoroacetic anhydride;

Reference yield:

: 1591826-98-0
5-bromo-3-(4-methoxybenzyl)-6-(trifluoromethyl)pyrimidin-4(3H)-one

: 1591824-21-3
3-chloro-5-((6-oxo-1-((6-oxo-5-phenyl-1,6-dihydropyridazin-3-yl)methyl)-4-(trifluoro methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate

2: acetonitrile; water

3: triethylamine / N,N-dimethyl-formamide

4: potassium phosphate / water

5: trifluoroacetic acid; trifluoroacetic anhydride

With potassium phosphate; potassium carbonate; triethylamine; In water; N,N-dimethyl-formamide; acetonitrile; trifluoroacetic acid; trifluoroacetic anhydride;