Cyano-acetic acid (1R,6R)-6-acetyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-2-enyl ester

Base Information

• Chemical Name: Cyano-acetic acid (1R,6R)-6-acetyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-2-enyl ester
• CAS No.: 75247-62-0
• Molecular Formula: C₁₉H₃₁NO₄Si
• Molecular Weight: 365.545
• Mol file: 75247-62-0.mol

Synonyms:Cyano-acetic acid (1R,6R)-6-acetyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-2-enyl ester

Chemical Property of Cyano-acetic acid (1R,6R)-6-acetyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-2-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyano-acetic acid (1R,6R)-6-acetyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-2-enyl ester

There total 2 articles about Cyano-acetic acid (1R,6R)-6-acetyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cyanoacetic acid chloride (16130-58-8) + cis-1-<1-<(tert-Butyldimethylsiloxy)methyl>-2-hydroxy-4-methyl-3-cyclohexenyl>-1-ethanone (75233-82-8) → Cyano-acetic acid (1R,6R)-6-acetyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-2-enyl ester (75247-62-0)

Guidance literature:

With pyridine; In diethyl ether; dichloromethane; at 0 ℃; for 0.25h;

DOI:10.1021/jo01312a004

Reference yield:

Acetic acid 6-acetyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-2-enyl ester (75233-80-6,75233-81-7) → Cyano-acetic acid (1R,6R)-6-acetyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-2-enyl ester (75247-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 33 percent / Potassium carbonate / methanol / 5 h / 0 °C

2: 100 percent / Pyridine / diethyl ether; CH₂Cl₂ / 0.25 h / 0 °C

With pyridine; potassium carbonate; In methanol; diethyl ether; dichloromethane;

DOI:10.1021/jo01312a004

upstream raw materials:

cyanoacetic acid chloride

cis-1-<1-<(tert-Butyldimethylsiloxy)methyl>-2-hydroxy-4-methyl-3-cyclohexenyl>-1-ethanone

Acetic acid 6-acetyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-2-enyl ester