methyl 4-((4S,10aS)-1,1-dimethyl-3-phenyl-3,4,10,10a-tetrahydro-1H-indeno[1,2-e][1,2]oxazepin-4-yl)benzoate

Base Information

Chemical Name:methyl 4-((4S,10aS)-1,1-dimethyl-3-phenyl-3,4,10,10a-tetrahydro-1H-indeno[1,2-e][1,2]oxazepin-4-yl)benzoate
CAS No.:1402404-07-2
Molecular Formula:C₂₈H₂₇NO₃
Molecular Weight:425.527
Hs Code.:

Synonyms:methyl 4-((4S,10aS)-1,1-dimethyl-3-phenyl-3,4,10,10a-tetrahydro-1H-indeno[1,2-e][1,2]oxazepin-4-yl)benzoate

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Chemical Property of methyl 4-((4S,10aS)-1,1-dimethyl-3-phenyl-3,4,10,10a-tetrahydro-1H-indeno[1,2-e][1,2]oxazepin-4-yl)benzoate

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Technology Process of methyl 4-((4S,10aS)-1,1-dimethyl-3-phenyl-3,4,10,10a-tetrahydro-1H-indeno[1,2-e][1,2]oxazepin-4-yl)benzoate

There total 3 articles about methyl 4-((4S,10aS)-1,1-dimethyl-3-phenyl-3,4,10,10a-tetrahydro-1H-indeno[1,2-e][1,2]oxazepin-4-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 26447-77-8,107379-16-8
C-(4-methoxycarbonylphenyl)-N-phenylnitrone

: 819871-63-1
1-ethynyl-2-(3-methylbut-2-en-1-yl)benzene

: 1402404-07-2
methyl 4-((4S,10aS)-1,1-dimethyl-3-phenyl-3,4,10,10a-tetrahydro-1H-indeno[1,2-e][1,2]oxazepin-4-yl)benzoate

Guidance literature:: With C₇₄H₁₀₄Au₂Cl₂O₆P₂; silver trifluoromethanesulfonate; In 1,1-dichloroethane; at 0 ℃; for 1h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201203507

Reference yield:

: 38274-16-7
2-bromo-1-(trimethylsilylethynyl)benzene

: 1402404-07-2
methyl 4-((4S,10aS)-1,1-dimethyl-3-phenyl-3,4,10,10a-tetrahydro-1H-indeno[1,2-e][1,2]oxazepin-4-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 - 25 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 26 °C / Inert atmosphere

3.1: C₇₄H₁₀₄Au₂Cl₂O₆P₂; silver trifluoromethanesulfonate / 1,1-dichloroethane / 1 h / 0 °C / Inert atmosphere

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; C₇₄H₁₀₄Au₂Cl₂O₆P₂; tetrabutyl ammonium fluoride; silver trifluoromethanesulfonate; In tetrahydrofuran; 1,1-dichloroethane;
DOI:10.1002/anie.201203507

Reference yield:

: 852390-09-1
trimethyl((2-(3-methylbut-2-en-1-yl)phenyl)ethynyl)silane

: 1402404-07-2
methyl 4-((4S,10aS)-1,1-dimethyl-3-phenyl-3,4,10,10a-tetrahydro-1H-indeno[1,2-e][1,2]oxazepin-4-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 26 °C / Inert atmosphere

2: C₇₄H₁₀₄Au₂Cl₂O₆P₂; silver trifluoromethanesulfonate / 1,1-dichloroethane / 1 h / 0 °C / Inert atmosphere

With C₇₄H₁₀₄Au₂Cl₂O₆P₂; tetrabutyl ammonium fluoride; silver trifluoromethanesulfonate; In tetrahydrofuran; 1,1-dichloroethane;
DOI:10.1002/anie.201203507