(1R,7S,8R,9S)-8,9-Dihydroxy-4-phenyl-2,4,6-triaza-tricyclo[5.2.1.0^2,6]decane-3,5-dione

Base Information

• Chemical Name: (1R,7S,8R,9S)-8,9-Dihydroxy-4-phenyl-2,4,6-triaza-tricyclo[5.2.1.0^2,6]decane-3,5-dione
• CAS No.: 195197-65-0
• Molecular Formula: C₁₃H₁₃N₃O₄
• Molecular Weight: 275.264

Synonyms:(1R,7S,8R,9S)-8,9-Dihydroxy-4-phenyl-2,4,6-triaza-tricyclo[5.2.1.0^2,6]decane-3,5-dione

Chemical Property of (1R,7S,8R,9S)-8,9-Dihydroxy-4-phenyl-2,4,6-triaza-tricyclo[5.2.1.0^2,6]decane-3,5-dione

Chemical Property:

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Technology Process of (1R,7S,8R,9S)-8,9-Dihydroxy-4-phenyl-2,4,6-triaza-tricyclo[5.2.1.0^2,6]decane-3,5-dione

There total 3 articles about (1R,7S,8R,9S)-8,9-Dihydroxy-4-phenyl-2,4,6-triaza-tricyclo[5.2.1.0^2,6]decane-3,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-phenyl-2,4,6-triazatricyclo[3.2.1.0(2,6)]dec-8-ene-3,5-dione (15971-63-8,137121-69-8,137121-70-1) → (1R,7S,8R,9S)-8,9-Dihydroxy-4-phenyl-2,4,6-triaza-tricyclo[5.2.1.02,6]decane-3,5-dione (195197-65-0)

Guidance literature:

With 4-methylmorpholine N-oxide; osmium(VIII) oxide; In water; acetone; for 24h; Yield given; Ambient temperature;

DOI:10.1016/S0040-4039(97)01227-6

Reference yield:

4-Phenyl-1,2,4-triazolidine-3,5-dione (4233-33-4) → (1R,7S,8R,9S)-8,9-Dihydroxy-4-phenyl-2,4,6-triaza-tricyclo[5.2.1.02,6]decane-3,5-dione (195197-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / CH₂Cl₂ / 0.5 h / Ambient temperature

2: N-methyl-morpholine oxide / OsO₄ / acetone; H₂O / 24 h / Ambient temperature

With 4-methylmorpholine N-oxide; osmium(VIII) oxide; In dichloromethane; water; acetone;

DOI:10.1016/S0040-4039(97)01227-6

Reference yield:

cyclopenta-1,3-diene (542-92-7,25568-84-7,7313-32-8) → (1R,7S,8R,9S)-8,9-Dihydroxy-4-phenyl-2,4,6-triaza-tricyclo[5.2.1.02,6]decane-3,5-dione (195197-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / CH₂Cl₂ / 0.5 h / Ambient temperature

2: N-methyl-morpholine oxide / OsO₄ / acetone; H₂O / 24 h / Ambient temperature

With 4-methylmorpholine N-oxide; osmium(VIII) oxide; In dichloromethane; water; acetone;

DOI:10.1016/S0040-4039(97)01227-6

upstream raw materials:

4-phenyl-2,4,6-triazatricyclo[3.2.1.0(2,6)]dec-8-ene-3,5-dione

4-Phenyl-1,2,4-triazolidine-3,5-dione

cyclopenta-1,3-diene

Downstream raw materials:

N-((1R,2S,3R,4S)-2,3-Dihydroxy-4-phenylacetylamino-cyclopentyl)-2-phenyl-acetamide

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