{3-[((9S,12S,15S)-15-tert-Butoxycarbonylamino-12-cyclohexyl-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetic acid benzyl ester

Base Information

• Chemical Name: {3-[((9S,12S,15S)-15-tert-Butoxycarbonylamino-12-cyclohexyl-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetic acid benzyl ester
• CAS No.: 371111-95-4
• Molecular Formula: C₄₆H₅₉N₅O₁₀
• Molecular Weight: 842.002

Synonyms:{3-[((9S,12S,15S)-15-tert-Butoxycarbonylamino-12-cyclohexyl-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetic acid benzyl ester

Chemical Property of {3-[((9S,12S,15S)-15-tert-Butoxycarbonylamino-12-cyclohexyl-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetic acid benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of {3-[((9S,12S,15S)-15-tert-Butoxycarbonylamino-12-cyclohexyl-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetic acid benzyl ester

There total 9 articles about {3-[((9S,12S,15S)-15-tert-Butoxycarbonylamino-12-cyclohexyl-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxy-3-nitrohexanoic acid (367258-42-2) → {3-[((9S,12S,15S)-15-tert-Butoxycarbonylamino-12-cyclohexyl-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.13,7]docosa-1(20),3,5,7(22),17(21),18-hexaene-9-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetic acid benzyl ester (371111-95-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 66 percent / H₂; AcOH / Pd/C / 3051.17 - 3102.89 Torr

2.1: 89 percent / aq. NaOH / dioxane / 0 - 20 °C

3.1: 94 percent / HOBt; N-methylmorpholine; EDCI / CH₂Cl₂; dimethylformamide / 12 h / -20 °C

4.1: HCl / dioxane / 2 h / 20 °C

5.1: HOBt; Huenigs base; EDCI / CH₂Cl₂

5.2: CH₂Cl₂ / cooling

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0489556

Reference yield:

3-tert-butoxycarbonylamino-2-hydroxyhexanoic acid (166196-06-1) → {3-[((9S,12S,15S)-15-tert-Butoxycarbonylamino-12-cyclohexyl-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.13,7]docosa-1(20),3,5,7(22),17(21),18-hexaene-9-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetic acid benzyl ester (371111-95-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 94 percent / HOBt; N-methylmorpholine; EDCI / CH₂Cl₂; dimethylformamide / 12 h / -20 °C

2.1: HCl / dioxane / 2 h / 20 °C

3.1: HOBt; Huenigs base; EDCI / CH₂Cl₂

3.2: CH₂Cl₂ / cooling

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0489556

Reference yield:

(3-tert-butoxycarbonylamino-2-hydroxyhexanoylamino)acetic acid benzyl ester (367258-43-3) → {3-[((9S,12S,15S)-15-tert-Butoxycarbonylamino-12-cyclohexyl-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.13,7]docosa-1(20),3,5,7(22),17(21),18-hexaene-9-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetic acid benzyl ester (371111-95-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: HCl / dioxane / 2 h / 20 °C

2.1: HOBt; Huenigs base; EDCI / CH₂Cl₂

2.2: CH₂Cl₂ / cooling

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm0489556

upstream raw materials:

[15S,12S,9S]-15-tert-butoxycarbonylamino-12-cyclohexyl-11,14-dioxo-2-oxa-10,13-diazatricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3⁽²²⁾,4,6,17⁽²¹⁾,18-hexaene-9-carboxylic acid

2-hydroxy-3-nitrohexanoic acid

3-tert-butoxycarbonylamino-2-hydroxyhexanoic acid

(3-tert-butoxycarbonylamino-2-hydroxyhexanoylamino)acetic acid benzyl ester

Downstream raw materials:

{3-[((9S,12S,15S)-15-tert-Butoxycarbonylamino-12-cyclohexyl-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carbonyl)-amino]-2-oxo-hexanoylamino}-acetic acid benzyl ester

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