(2S,3R)-benzyl 3-((tert-butoxycarbonyl)methyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate

Base Information

Chemical Name:(2S,3R)-benzyl 3-((tert-butoxycarbonyl)methyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate
CAS No.:1152739-12-2
Molecular Formula:C₃₇H₃₅NO₅
Molecular Weight:573.689
Hs Code.:

Synonyms:(2S,3R)-benzyl 3-((tert-butoxycarbonyl)methyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate

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Chemical Property of (2S,3R)-benzyl 3-((tert-butoxycarbonyl)methyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate

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Technology Process of (2S,3R)-benzyl 3-((tert-butoxycarbonyl)methyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate

There total 2 articles about (2S,3R)-benzyl 3-((tert-butoxycarbonyl)methyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: (2S)-benzyl 3-((tert-butoxycarbonyl)methyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate

: 1152739-01-9
(2S,3S)-benzyl 3-((tert-butoxycarbonyl)methyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate

: 1152739-12-2
(2S,3R)-benzyl 3-((tert-butoxycarbonyl)methyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; Inert atmosphere;
DOI:10.1021/jo802679n

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 163594-14-7
(2S)-4-oxo-N-(9-phenylfluoren-9-yl)proline benzyl ester

: 1152739-01-9
(2S,3S)-benzyl 3-((tert-butoxycarbonyl)methyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate

: 1152739-12-2
(2S,3R)-benzyl 3-((tert-butoxycarbonyl)methyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate

Guidance literature:: (2S)-4-oxo-N-(9-phenylfluoren-9-yl)proline benzyl ester; With n-butyllithium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexanes; at -78 ℃; Inert atmosphere;

bromoacetic acid tert-butyl ester; With sodium iodide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexanes; at -40 ℃; for 3h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/jo802679n