1,7,8-triaza-1-benzyl-6,6-dimethyl-5-oxa-2-oxo-3,3-diphenylspiro<3.4>oct-7-ene

Base Information

• Chemical Name: 1,7,8-triaza-1-benzyl-6,6-dimethyl-5-oxa-2-oxo-3,3-diphenylspiro<3.4>oct-7-ene
• CAS No.: 134209-92-0
• Molecular Formula: C₂₅H₂₃N₃O₂
• Molecular Weight: 397.477
• Mol file: 134209-92-0.mol

Synonyms:1,7,8-triaza-1-benzyl-6,6-dimethyl-5-oxa-2-oxo-3,3-diphenylspiro<3.4>oct-7-ene

Chemical Property of 1,7,8-triaza-1-benzyl-6,6-dimethyl-5-oxa-2-oxo-3,3-diphenylspiro<3.4>oct-7-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,7,8-triaza-1-benzyl-6,6-dimethyl-5-oxa-2-oxo-3,3-diphenylspiro<3.4>oct-7-ene

There total 4 articles about 1,7,8-triaza-1-benzyl-6,6-dimethyl-5-oxa-2-oxo-3,3-diphenylspiro<3.4>oct-7-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

diphenylacetic acid chloride (1871-76-7) + 2-benzylimino-5,5-dimethyl-Δ3-1,3,4-oxadiazoline (21449-51-4) → 1,7,8-triaza-1-benzyl-6,6-dimethyl-5-oxa-2-oxo-3,3-diphenylspiro<3.4>oct-7-ene (134209-92-0)

Guidance literature:

With triethylamine; In dichloromethane; -23 deg C to r.t.;

DOI:10.1139/v92-378

Reference yield:

propan-2-one 4-benzyl-semicarbazone (134358-53-5) → 1,7,8-triaza-1-benzyl-6,6-dimethyl-5-oxa-2-oxo-3,3-diphenylspiro<3.4>oct-7-ene (134209-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Pb(OAc)4, K₂CO₃ / CH₂Cl₂

2: 80 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With lead(IV) acetate; potassium carbonate; triethylamine; In dichloromethane;

Reference yield:

diphenylacetic acid chloride (1871-76-7) + benzyl-(5,5-dimethyl-5H-[1,3,4]oxadiazol-2-ylidene)-amine (134209-86-2) → 1,7,8-triaza-1-benzyl-6,6-dimethyl-5-oxa-2-oxo-3,3-diphenylspiro<3.4>oct-7-ene (134209-92-0)

Guidance literature:

With triethylamine; In dichloromethane; Yield given; 1) -23 deg C, 2) rt, overnight;

DOI:10.1021/jo00010a008

upstream raw materials:

diphenylacetic acid chloride

benzyl-(5,5-dimethyl-5H-[1,3,4]oxadiazol-2-ylidene)-amine

2-benzylimino-5,5-dimethyl-Δ³-1,3,4-oxadiazoline

2,2-diphenylacetic acid

Downstream raw materials:

acetone