C₂₀H₁₆N₄O₅

Base Information

• Chemical Name: C₂₀H₁₆N₄O₅
• CAS No.: 1309611-47-9
• Molecular Formula: C₂₀H₁₆N₄O₅
• Molecular Weight: 392.371
• Mol file: 1309611-47-9.mol

Synonyms:C₂₀H₁₆N₄O₅

Chemical Property of C₂₀H₁₆N₄O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₁₆N₄O₅

There total 10 articles about C₂₀H₁₆N₄O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 6-(benzyloxycarbonylamino)-pyridine-2-carboxylate (1262043-88-8) → C20H16N4O5 (1309611-47-9)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 3 h / 50 °C

2: tetrahydrofuran; N,N-dimethyl-formamide / 0 - 90 °C

3: sodium hydroxide / 1,4-dioxane; water

With palladium 10% on activated carbon; hydrogen; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.1039/c1cc11532d

Reference yield:

2,6-bis(methoxycarbonyl)pyridine (5453-67-8) → C20H16N4O5 (1309611-47-9)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium hydroxide / water / 12 h / 20 °C

2: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / -10 - -5 °C

3: sodium azide / tetrahydrofuran; water; N,N-dimethyl-formamide / 0.5 h / Cooling

4: toluene / 30 h / 120 °C

5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 3 h / 50 °C

6: tetrahydrofuran; N,N-dimethyl-formamide / 0 - 90 °C

7: sodium hydroxide / 1,4-dioxane; water

With 4-methyl-morpholine; sodium azide; palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;

DOI:10.1039/c1cc11532d

Reference yield:

Pyridine-2,6-dicarboxylic acid (499-83-2) → C20H16N4O5 (1309611-47-9)

Guidance literature:

Multi-step reaction with 8 steps

1: sulfuric acid / 48 h / Reflux

2: sodium hydroxide / water / 12 h / 20 °C

3: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / -10 - -5 °C

4: sodium azide / tetrahydrofuran; water; N,N-dimethyl-formamide / 0.5 h / Cooling

5: toluene / 30 h / 120 °C

6: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 3 h / 50 °C

7: tetrahydrofuran; N,N-dimethyl-formamide / 0 - 90 °C

8: sodium hydroxide / 1,4-dioxane; water

With 4-methyl-morpholine; sodium azide; sulfuric acid; palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;

DOI:10.1039/c1cc11532d

upstream raw materials:

2,6-bis(methoxycarbonyl)pyridine

methyl 6-aminopyridine-2-carboxylate

methyl 6-(benzyloxycarbonylamino)-pyridine-2-carboxylate

C₁₄H₁₂N₂O₄

Downstream raw materials:

C₂₇H₂₂N₆O₆

C₂₈H₂₄N₆O₇

C₃₃H₂₆N₈O₇

C₃₇H₂₈N₁₀O₆