1a-amino-8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-(methyloxy)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide hydrochloride

Base Information

• Chemical Name: 1a-amino-8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-(methyloxy)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide hydrochloride
• CAS No.: 959983-12-1
• Molecular Formula: C₂₈H₃₄N₄O₄S*ClH
• Molecular Weight: 559.129
• Mol file: 959983-12-1.mol

Synonyms:1a-amino-8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-(methyloxy)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide hydrochloride

Chemical Property of 1a-amino-8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-(methyloxy)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1a-amino-8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-(methyloxy)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide hydrochloride

There total 17 articles about 1a-amino-8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-(methyloxy)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl (8-cyclohexyl-5-((((dimethylamino)sulfonyl)amino)carbonyl)-11-(methyloxy)-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepin-1a(2H)-yl)carbamate (959983-11-0) → 1a-amino-8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-(methyloxy)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide hydrochloride (959983-12-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 3.58333h;

Reference yield:

Indole-6-carboxylic acid (1670-82-2,261352-47-0) → 1a-amino-8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-(methyloxy)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide hydrochloride (959983-12-1)

Guidance literature:

Multi-step reaction with 12 steps

1.1: diethyl ether / 1 h / -15 °C

2.1: triethylsilane; trifluoroacetic acid / dichloromethane / 12 h / 10 - 20 °C

3.1: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 2 - 2.66 h / 0 - 20 °C

4.1: methanol; lithium hydroxide; water / tetrahydrofuran / 2 - 3 h / 90 °C

4.2: 1 h / 0 - 20 °C

5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 - 2.16 h / 22 - 50 °C

5.2: 21 - 24 h / 20 - 30 °C

6.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 70 °C

7.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 55 °C

8.1: sodium hydride / dimethyl sulfoxide / 0.5 - 0.67 h / 20 °C

8.2: 2.75 - 6 h / 20 - 55 °C

9.1: methanol; sodium hydroxide; water / tetrahydrofuran / 6.25 h / 20 °C

10.1: diphenyl phosphoryl azide; triethylamine / toluene / 2.5 h / 20 °C

11.1: toluene / 1.75 h / 120 °C

11.2: 1.75 h / 120 °C

12.1: hydrogenchloride / 1,4-dioxane / 3.58 h / 20 °C

With hydrogenchloride; methanol; triethylsilane; lithium hydroxide; sodium hydroxide; diphenyl phosphoryl azide; water; sodium hydride; sodium carbonate; caesium carbonate; pyridinium hydrobromide perbromide; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1a-amino-8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-(methyloxy)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide hydrochloride (959983-12-1)

Guidance literature:

Multi-step reaction with 11 steps

1.1: triethylsilane; trifluoroacetic acid / dichloromethane / 12 h / 10 - 20 °C

2.1: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 2 - 2.66 h / 0 - 20 °C

3.1: methanol; lithium hydroxide; water / tetrahydrofuran / 2 - 3 h / 90 °C

3.2: 1 h / 0 - 20 °C

4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 - 2.16 h / 22 - 50 °C

4.2: 21 - 24 h / 20 - 30 °C

5.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 70 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 55 °C

7.1: sodium hydride / dimethyl sulfoxide / 0.5 - 0.67 h / 20 °C

7.2: 2.75 - 6 h / 20 - 55 °C

8.1: methanol; sodium hydroxide; water / tetrahydrofuran / 6.25 h / 20 °C

9.1: diphenyl phosphoryl azide; triethylamine / toluene / 2.5 h / 20 °C

10.1: toluene / 1.75 h / 120 °C

10.2: 1.75 h / 120 °C

11.1: hydrogenchloride / 1,4-dioxane / 3.58 h / 20 °C

With hydrogenchloride; methanol; triethylsilane; lithium hydroxide; sodium hydroxide; diphenyl phosphoryl azide; water; sodium hydride; sodium carbonate; caesium carbonate; pyridinium hydrobromide perbromide; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

upstream raw materials:

1,1-dimethylethyl (8-cyclohexyl-5-((((dimethylamino)sulfonyl)amino)carbonyl)-11-(methyloxy)-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepin-1a(2H)-yl)carbamate

methyl 3-cyclohexyl-1H-indole-6-carboxylate

3-cyclohexyl-1-methyl-1H-indole-6-carboxylic acid

3-(cyclohex-1-en-1-yl)-1H-indole-6-carboxylic acid

Downstream raw materials:

8-cyclohexyl-N-(dimethylsulfamoyl)-11-methoxy-1a-((4-morpholinylsulfonyl)amino)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-(methyloxy)-1a-((4-morpholinyl(oxo)acetyl)amino)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide