(1R,2R,3R)-1-(4-allyloxy-3-methoxyphenyl)-4-(4-benzyloxy-3-methoxyphenyl)-4-methoxymethoxy-2,3-dimethylbutan-1-ol

Base Information

Chemical Name:(1R,2R,3R)-1-(4-allyloxy-3-methoxyphenyl)-4-(4-benzyloxy-3-methoxyphenyl)-4-methoxymethoxy-2,3-dimethylbutan-1-ol
CAS No.:935431-18-8
Molecular Formula:C₃₂H₄₀O₇
Molecular Weight:536.665
Hs Code.:

Synonyms:(1R,2R,3R)-1-(4-allyloxy-3-methoxyphenyl)-4-(4-benzyloxy-3-methoxyphenyl)-4-methoxymethoxy-2,3-dimethylbutan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R,3R)-1-(4-allyloxy-3-methoxyphenyl)-4-(4-benzyloxy-3-methoxyphenyl)-4-methoxymethoxy-2,3-dimethylbutan-1-ol

Chemical Property:

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Technology Process of (1R,2R,3R)-1-(4-allyloxy-3-methoxyphenyl)-4-(4-benzyloxy-3-methoxyphenyl)-4-methoxymethoxy-2,3-dimethylbutan-1-ol

There total 7 articles about (1R,2R,3R)-1-(4-allyloxy-3-methoxyphenyl)-4-(4-benzyloxy-3-methoxyphenyl)-4-methoxymethoxy-2,3-dimethylbutan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(1R,2R,3R)-1-(4-Allyloxy-3-methoxy-phenyl)-4-(4-benzyloxy-3-methoxy-phenyl)-4-methoxymethoxy-2,3-dimethyl-butoxy]-tert-butyl-dimethyl-silane

: 935431-18-8
(1R,2R,3R)-1-(4-allyloxy-3-methoxyphenyl)-4-(4-benzyloxy-3-methoxyphenyl)-4-methoxymethoxy-2,3-dimethylbutan-1-ol

: 915158-86-0
(1R,2R,3R)-1-(4-allyloxy-3-methoxyphenyl)-4-(4-benzyloxy-3-methoxyphenyl)-4-methoxymethoxy-2,3-dimethylbutan-1-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h; Title compound not separated from byproducts;
DOI:10.1021/ol0621710

Reference yield:

: (2R,3R,4R)-4-(4-allyloxy-3-methoxyphenyl)-1-(4-benzyloxy-3-methoxyphenyl)-4-(tert-butyldimethylsilanyloxy)-2,3-dimethylbutan-1-ol

: 935431-18-8
(1R,2R,3R)-1-(4-allyloxy-3-methoxyphenyl)-4-(4-benzyloxy-3-methoxyphenyl)-4-methoxymethoxy-2,3-dimethylbutan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: DMP

2: CeCl₃; NaBH₄ / methanol; CH₂Cl₂

3: Huenig's base

4: TBAF / tetrahydrofuran

With sodium tetrahydroborate; cerium(III) chloride; phthalic acid dimethyl ester; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; 1: Dess-Martin oxidation;
DOI:10.1055/s-2007-968019