2-(5-methylfuran-2-yl)-6-phenyl-N-(pyridin-3-yl)quinoline-4-carboxamide

Base Information

Chemical Name:2-(5-methylfuran-2-yl)-6-phenyl-N-(pyridin-3-yl)quinoline-4-carboxamide
CAS No.:1549772-61-3
Molecular Formula:C₂₆H₁₉N₃O₂
Molecular Weight:405.456
Hs Code.:

Synonyms:2-(5-methylfuran-2-yl)-6-phenyl-N-(pyridin-3-yl)quinoline-4-carboxamide

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Chemical Property of 2-(5-methylfuran-2-yl)-6-phenyl-N-(pyridin-3-yl)quinoline-4-carboxamide

Chemical Property:

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Technology Process of 2-(5-methylfuran-2-yl)-6-phenyl-N-(pyridin-3-yl)quinoline-4-carboxamide

There total 5 articles about 2-(5-methylfuran-2-yl)-6-phenyl-N-(pyridin-3-yl)quinoline-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62306-79-0
5-methylfuran-2-boronic acid

: 1549775-81-6
2-chloro-6-phenyl-N-(pyridin-3-yl)quinoline-4-carboxamide

: 1549772-61-3
2-(5-methylfuran-2-yl)-6-phenyl-N-(pyridin-3-yl)quinoline-4-carboxamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 5h; Inert atmosphere;

Reference yield:

: 5463-29-6
6-bromo-2-hydroxyquinoline-4-carboxylic acid

: 1549772-61-3
2-(5-methylfuran-2-yl)-6-phenyl-N-(pyridin-3-yl)quinoline-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / dichloromethane; ethyl acetate / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere

3: trichlorophosphate / 4 h / Reflux

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,4-dioxane / 5 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 2: |Suzuki Coupling / 4: |Suzuki Coupling;

Reference yield:

: 1549775-70-3
6-bromo-2-hydroxy-N-(pyridin-3-yl)quinoline-4-carboxamide

: 1549772-61-3
2-(5-methylfuran-2-yl)-6-phenyl-N-(pyridin-3-yl)quinoline-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere

2: trichlorophosphate / 4 h / Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,4-dioxane / 5 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; trichlorophosphate; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1: |Suzuki Coupling / 3: |Suzuki Coupling;