tert-butyl 4-((2-(5-cyanopyrazin-2-ylamino)-5-(4-methoxyphenyl)pyridin-4-ylamino)methyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((2-(5-cyanopyrazin-2-ylamino)-5-(4-methoxyphenyl)pyridin-4-ylamino)methyl)piperidine-1-carboxylate
CAS No.:1137477-94-1
Molecular Formula:C₂₈H₃₃N₇O₃
Molecular Weight:515.615
Hs Code.:

Synonyms:tert-butyl 4-((2-(5-cyanopyrazin-2-ylamino)-5-(4-methoxyphenyl)pyridin-4-ylamino)methyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-((2-(5-cyanopyrazin-2-ylamino)-5-(4-methoxyphenyl)pyridin-4-ylamino)methyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-((2-(5-cyanopyrazin-2-ylamino)-5-(4-methoxyphenyl)pyridin-4-ylamino)methyl)piperidine-1-carboxylate

There total 8 articles about tert-butyl 4-((2-(5-cyanopyrazin-2-ylamino)-5-(4-methoxyphenyl)pyridin-4-ylamino)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 221295-04-1
5-bromopyrazine-2-carbonitrile

: 1137477-93-0
tert-butyl 4-((2-amino-5-(4-methoxyphenyl)pyridin-4-ylamino)methyl)piperidine-1-carboxylate

: 1137477-94-1
tert-butyl 4-((2-(5-cyanopyrazin-2-ylamino)-5-(4-methoxyphenyl)pyridin-4-ylamino)methyl)piperidine-1-carboxylate

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In Dimethyl ether; at 100 ℃; for 1.16667h; Microwave irradiation;

Reference yield:

: 1137477-51-0
N-(5-bromo-4-chloropyridin-2-yl)pivalamide

: 1137477-94-1
tert-butyl 4-((2-(5-cyanopyrazin-2-ylamino)-5-(4-methoxyphenyl)pyridin-4-ylamino)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 210 °C / Microwave irradiation

2: hydrogenchloride; water / 45 h / 105 °C / Microwave irradiation

3: triethylamine / dichloromethane / 1 h / 0 - 20 °C

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 0.33 h / 150 °C / Microwave irradiation

5: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / Dimethyl ether / 1.17 h / 100 °C / Microwave irradiation

With hydrogenchloride; water; sodium carbonate; caesium carbonate; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1-methyl-pyrrolidin-2-one; Dimethyl ether; dichloromethane; water; acetonitrile;

Reference yield:

: 19798-80-2
2-Amino-4-chloropyridine

: 1137477-94-1
tert-butyl 4-((2-(5-cyanopyrazin-2-ylamino)-5-(4-methoxyphenyl)pyridin-4-ylamino)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / 12 h / 0 - 20 °C

2: N-Bromosuccinimide / acetonitrile / 3 h

3: triethylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 210 °C / Microwave irradiation

4: hydrogenchloride; water / 45 h / 105 °C / Microwave irradiation

5: triethylamine / dichloromethane / 1 h / 0 - 20 °C

6: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 0.33 h / 150 °C / Microwave irradiation

7: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / Dimethyl ether / 1.17 h / 100 °C / Microwave irradiation

With pyridine; hydrogenchloride; N-Bromosuccinimide; water; sodium carbonate; caesium carbonate; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1-methyl-pyrrolidin-2-one; Dimethyl ether; dichloromethane; water; acetonitrile;