Technology Process of 3-allyl-6-chloro-2,3,4,5-tetrahydro-1(3-hydroxyphenyl)-1H-3-benzazepine-7,8-diol
There total 6 articles about 3-allyl-6-chloro-2,3,4,5-tetrahydro-1(3-hydroxyphenyl)-1H-3-benzazepine-7,8-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron tribromide;
In
dichloromethane;
at 0 - 20 ℃;
for 3.5h;
DOI:10.1021/jm00155a024
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 38 percent / tetrahydrofuran / 16 h / Heating
2: 91 percent / trifluoroacetic acid, conc. aq. H2SO4 / 3 h / Heating
3: K2CO3 / dimethylformamide; H2O; CH2Cl2 / 6 h / Ambient temperature
4: boron tribromide / CH2Cl2 / 3.5 h / 0 - 20 °C
With
sulfuric acid; boron tribromide; potassium carbonate; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00155a024
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 38 percent / tetrahydrofuran / 16 h / Heating
2: 91 percent / trifluoroacetic acid, conc. aq. H2SO4 / 3 h / Heating
3: K2CO3 / dimethylformamide; H2O; CH2Cl2 / 6 h / Ambient temperature
4: boron tribromide / CH2Cl2 / 3.5 h / 0 - 20 °C
With
sulfuric acid; boron tribromide; potassium carbonate; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00155a024
