Technology Process of cyclopropanecarboxylic acid 3-(2,5-dimethyl-phenyl)-8-methoxy-1-methoxymethoxy-2-oxo-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester
There total 7 articles about cyclopropanecarboxylic acid 3-(2,5-dimethyl-phenyl)-8-methoxy-1-methoxymethoxy-2-oxo-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydroxylamine hydrochloride; triethylamine / methanol / 1.5 h / Reflux
2.1: potassium dihydrogenphosphate / water / 0 - 20 °C
3.1: sodium hydrogencarbonate / ethyl acetate; water / 4 h / 0 - 20 °C
4.1: sulfuric acid / 40 h / 0 °C / Reflux
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
5.2: 2.5 h / 0 - 20 °C
5.3: 2.5 h / 20 °C
6.1: triethylamine / dmap / tetrahydrofuran / 1.17 h / 0 - 20 °C
With
potassium dihydrogenphosphate; sulfuric acid; hydroxylamine hydrochloride; sodium hydride; sodium hydrogencarbonate; triethylamine;
dmap;
In
tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / ethyl acetate; water / 4 h / 0 - 20 °C
2.1: sulfuric acid / 40 h / 0 °C / Reflux
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
3.2: 2.5 h / 0 - 20 °C
3.3: 2.5 h / 20 °C
4.1: triethylamine / dmap / tetrahydrofuran / 1.17 h / 0 - 20 °C
With
sulfuric acid; sodium hydride; sodium hydrogencarbonate; triethylamine;
dmap;
In
tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium dihydrogenphosphate / water / 0 - 20 °C
2.1: sodium hydrogencarbonate / ethyl acetate; water / 4 h / 0 - 20 °C
3.1: sulfuric acid / 40 h / 0 °C / Reflux
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
4.2: 2.5 h / 0 - 20 °C
4.3: 2.5 h / 20 °C
5.1: triethylamine / dmap / tetrahydrofuran / 1.17 h / 0 - 20 °C
With
potassium dihydrogenphosphate; sulfuric acid; sodium hydride; sodium hydrogencarbonate; triethylamine;
dmap;
In
tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
