2-(4-Amino-phenyl)-N-[2'-(2-dimethylamino-ethylamino)-biphenyl-2-yl]-acetamide

Base Information

• Chemical Name: 2-(4-Amino-phenyl)-N-[2'-(2-dimethylamino-ethylamino)-biphenyl-2-yl]-acetamide
• CAS No.: 76751-82-1
• Molecular Formula: C₂₄H₂₈N₄O
• Molecular Weight: 388.513
• Mol file: 76751-82-1.mol

Synonyms:2-(4-Amino-phenyl)-N-[2'-(2-dimethylamino-ethylamino)-biphenyl-2-yl]-acetamide

Chemical Property of 2-(4-Amino-phenyl)-N-[2'-(2-dimethylamino-ethylamino)-biphenyl-2-yl]-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Amino-phenyl)-N-[2'-(2-dimethylamino-ethylamino)-biphenyl-2-yl]-acetamide

There total 5 articles about 2-(4-Amino-phenyl)-N-[2'-(2-dimethylamino-ethylamino)-biphenyl-2-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

N-[2'-(2-Dimethylamino-ethylamino)-biphenyl-2-yl]-2-(4-nitro-phenyl)-acetamide (76751-75-2) → 2-(4-Amino-phenyl)-N-[2'-(2-dimethylamino-ethylamino)-biphenyl-2-yl]-acetamide (76751-82-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; under 2280 Torr; Ambient temperature;

DOI:10.1021/jm00137a029

Reference yield:

1,1'-biphenyl-2,2'-diamine (1454-80-4) → 2-(4-Amino-phenyl)-N-[2'-(2-dimethylamino-ethylamino)-biphenyl-2-yl]-acetamide (76751-82-1)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 20 h / Heating

2: acetic acid / 20 h / 60 °C

3: 52 percent / H₂ / Pd/C / tetrahydrofuran; methanol / 2280 Torr / Ambient temperature

With hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jm00137a029

Reference yield:

4-Nitrophenylacetonitrile (555-21-5,34512-13-5,174848-08-9) → 2-(4-Amino-phenyl)-N-[2'-(2-dimethylamino-ethylamino)-biphenyl-2-yl]-acetamide (76751-82-1)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl(gas) / CHCl₃ / 0 °C

2: acetic acid / 20 h / 60 °C

3: 52 percent / H₂ / Pd/C / tetrahydrofuran; methanol / 2280 Torr / Ambient temperature

With hydrogenchloride; hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform;

DOI:10.1021/jm00137a029

upstream raw materials:

N-[2'-(2-Dimethylamino-ethylamino)-biphenyl-2-yl]-2-(4-nitro-phenyl)-acetamide

1,1'-biphenyl-2,2'-diamine

4-Nitrophenylacetonitrile

ethyl 2-(4-nitrophenyl)acetimidate hydrochloride