N-(5-(3-(dimethylamino)-1-phenylpropoxy)pyrimidin-2-yl)-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide

Base Information

Chemical Name:N-(5-(3-(dimethylamino)-1-phenylpropoxy)pyrimidin-2-yl)-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide
CAS No.:1584112-50-4
Molecular Formula:C₂₆H₂₈F₃N₅O₃
Molecular Weight:515.535
Hs Code.:

Synonyms:N-(5-(3-(dimethylamino)-1-phenylpropoxy)pyrimidin-2-yl)-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide

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Chemical Property of N-(5-(3-(dimethylamino)-1-phenylpropoxy)pyrimidin-2-yl)-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide

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Technology Process of N-(5-(3-(dimethylamino)-1-phenylpropoxy)pyrimidin-2-yl)-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide

There total 3 articles about N-(5-(3-(dimethylamino)-1-phenylpropoxy)pyrimidin-2-yl)-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1584114-02-2
4-nitrophenyl 5-methoxy-6-(trifluoromethyl)indoline-1-carboxylate

: 1584114-04-4
5-(3-(dimethylamino)-1-phenylpropoxy)pyrimidin-2-amine

: 1584112-50-4
N-(5-(3-(dimethylamino)-1-phenylpropoxy)pyrimidin-2-yl)-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide

Guidance literature:: 5-(3-(dimethylamino)-1-phenylpropoxy)pyrimidin-2-amine; With lithium hexamethyldisilazane; In tetrahydrofuran; ethylbenzene; at 0 ℃; for 0.25h; Inert atmosphere;

4-nitrophenyl 5-methoxy-6-(trifluoromethyl)indoline-1-carboxylate; In tetrahydrofuran; ethylbenzene; at 20 ℃; for 2h;

Reference yield:

: 178896-79-2
5-methoxy-6-(trifluoromethyl)indoline

: 1584112-50-4
N-(5-(3-(dimethylamino)-1-phenylpropoxy)pyrimidin-2-yl)-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran; ethylbenzene / 0.25 h / 0 °C / Inert atmosphere

2.2: 2 h / 20 °C

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethylbenzene;

Reference yield:

: 1584114-03-3
N-(5-(3-(dimethylamino)-1-phenylpropoxy)pyrimidin-2-yl)acetamide

: 1584112-50-4
N-(5-(3-(dimethylamino)-1-phenylpropoxy)pyrimidin-2-yl)-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol / 3 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran; ethylbenzene / 0.25 h / 0 °C / Inert atmosphere

2.2: 2 h / 20 °C

With sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethylbenzene;