(1,2-distearoyl-rac-3-glycero)-O-benzyl diethylamidophosphite

Base Information

• Chemical Name: (1,2-distearoyl-rac-3-glycero)-O-benzyl diethylamidophosphite
• CAS No.: 75257-05-5
• Molecular Formula: C₅₀H₉₂NO₆P
• Molecular Weight: 834.257
• Mol file: 75257-05-5.mol

Synonyms:(1,2-distearoyl-rac-3-glycero)-O-benzyl diethylamidophosphite

Chemical Property of (1,2-distearoyl-rac-3-glycero)-O-benzyl diethylamidophosphite

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1,2-distearoyl-rac-3-glycero)-O-benzyl diethylamidophosphite

There total 1 articles about (1,2-distearoyl-rac-3-glycero)-O-benzyl diethylamidophosphite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

DL-α,β-distearin (51063-97-9) + benzyl tetraethylphosphorodiamidite (66954-57-2) → (1,2-distearoyl-rac-3-glycero)-O-benzyl diethylamidophosphite (75257-05-5)

Guidance literature:

at 90 ℃; for 1.5h; atmosphere of dry argon;

Reference yield:

(1,2-distearoyl-rac-3-glycero)-O-benzyl diethylamidophosphite (75257-05-5) → 1,2-di-O-stearoyl-rac-3-glycerophosphate (17966-25-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 2 h / 105 °C / atmosphere of dry argon

2: iodosylbenzene / benzene / 1 h / 18 - 20 °C

3: NaI / acetone / 1.5 h / Heating

4: KRS-40T resin in H⁺ form / CHCl₃; methanol; H₂O / 0.25 h / 18 - 20 °C

5: 42 percent / H₂ / palladium black / CHCl₃; methanol / 1 h

With iodosylbenzene; KRS-40T resin in H⁺ form; hydrogen; sodium iodide; palladium; In methanol; chloroform; water; acetone; benzene;

Reference yield:

(1,2-distearoyl-rac-3-glycero)-O-benzyl diethylamidophosphite (75257-05-5) → Octadecanoic acid 2-(benzyloxy-diethylamino-phosphoryloxy)-1-octadecanoyloxymethyl-ethyl ester (75257-13-5)

Guidance literature:

With iodosylbenzene; In benzene; at 18 - 20 ℃; for 3h; Yield given;

upstream raw materials:

DL-α,β-distearin

benzyl tetraethylphosphorodiamidite

Downstream raw materials:

O-(1,2-distearoyl-rac-3-glycero) O-(N-methyl-N-benzylaminoethyl) O-benzyl phosphite

Octadecanoic acid 2-(benzyloxy-diethylamino-phosphoryloxy)-1-octadecanoyloxymethyl-ethyl ester

1,2-distearoylglycerol dibenzyl phosphite

1,2-di-O-stearoyl-rac-3-glycerophosphate

Refernces

• 1、 Smirnova, L.I.,Malenkovskaya, M. A.,Predvoditelev, D. A.,Nifant'ev, E. E.. "A new approach to the synthesis of phosphatidic acids and their analogs". . p. 1011 - 1019. Retrieved 2007/10/02.