(E)-pent-2-en-4-ynoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide

Base Information

Chemical Name:(E)-pent-2-en-4-ynoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide
CAS No.:1245710-88-6
Molecular Formula:C₂₃H₁₆ClFN₄O₂
Molecular Weight:434.857
Hs Code.:

Synonyms:(E)-pent-2-en-4-ynoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide

Suppliers and Price of (E)-pent-2-en-4-ynoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide

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Chemical Property of (E)-pent-2-en-4-ynoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide

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Technology Process of (E)-pent-2-en-4-ynoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide

There total 2 articles about (E)-pent-2-en-4-ynoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 41345-43-1
(E)-5-pent-2-en-4-ynoic acid methyl ester

: 361162-95-0
6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile

: 1245710-88-6
(E)-pent-2-en-4-ynoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide

Guidance literature:: With trimethylaluminum; In hexane; dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2010.08.004

Reference yield: 20.0%

: 1245710-88-6
(E)-pent-2-en-4-ynoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide

Guidance literature:

Reference yield: 32.0%

: 894792-94-0
1-azido-2-fluoroethane

: 1245710-88-6
(E)-pent-2-en-4-ynoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide

: 1245710-96-6
(E)-N-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-3-[1-(2-fluoroethyl)-1H-[1,2,3]triazol-4-yl]-acrylamide

Guidance literature:: With copper; copper(II) sulfate; In water; N,N-dimethyl-formamide; at 125 ℃; for 0.25h; Microwave irradiation;
DOI:10.1016/j.bmc.2010.08.004