methyl (E)-3-(4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl]methyl}-1H-imidazol-5-yl)-2-propenoate

Base Information

Chemical Name:methyl (E)-3-(4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl]methyl}-1H-imidazol-5-yl)-2-propenoate
CAS No.:150438-34-9
Molecular Formula:C₃₀H₃₁N₇O₂
Molecular Weight:521.622
Hs Code.:

Synonyms:methyl (E)-3-(4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl]methyl}-1H-imidazol-5-yl)-2-propenoate

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Chemical Property of methyl (E)-3-(4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl]methyl}-1H-imidazol-5-yl)-2-propenoate

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Technology Process of methyl (E)-3-(4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl]methyl}-1H-imidazol-5-yl)-2-propenoate

There total 8 articles about methyl (E)-3-(4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl]methyl}-1H-imidazol-5-yl)-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 150438-33-8
Methyl (E)-3-[4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-propyl-1-[[2'-2-(triphenylmethyl)-2H-tetrazol-5-yl]-1,1'-biphenyl-4-yl]methyl-1H-imidazol-5-yl]-2-propenoate

: 150438-34-9
methyl (E)-3-(4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl]methyl}-1H-imidazol-5-yl)-2-propenoate

Guidance literature:: With citric acid; In methanol; for 0.5h; Heating;
DOI:10.1021/jm00068a002

Reference yield:

: methyl N-cyanobutyrimidate

: 150438-34-9
methyl (E)-3-(4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl]methyl}-1H-imidazol-5-yl)-2-propenoate

Guidance literature:: Multi-step reaction with 8 steps

1: 370 g / Et₃N / methanol / 17 h / 20 °C

2: 38 percent / NaOMe / methanol / 1.) RT, 1 h, 2.) reflux, 1 h

3: 70 percent / AcOH / ethanol / 6 h / Heating

4: 45 percent / LiAlH₄ / tetrahydrofuran / 18 h / Ambient temperature

5: 75 percent / MnO₂ / tetrahydrofuran / 4 h / Heating

6: 5.62 g / Cs₂CO₃ / dimethylformamide / 6 h

7: 2.7 g / toluene / 0.5 h / Heating

8: 24 percent / 10percent aq. citric acid / methanol / 0.5 h / Heating

With manganese(IV) oxide; lithium aluminium tetrahydride; sodium methylate; caesium carbonate; acetic acid; triethylamine; citric acid; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00068a002

Reference yield:

: 150437-95-9
methyl N-(N'-cyanobutyrimidoyl)glycinate

: 150438-34-9
methyl (E)-3-(4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl]methyl}-1H-imidazol-5-yl)-2-propenoate

Guidance literature:: Multi-step reaction with 7 steps

1: 38 percent / NaOMe / methanol / 1.) RT, 1 h, 2.) reflux, 1 h

2: 70 percent / AcOH / ethanol / 6 h / Heating

3: 45 percent / LiAlH₄ / tetrahydrofuran / 18 h / Ambient temperature

4: 75 percent / MnO₂ / tetrahydrofuran / 4 h / Heating

5: 5.62 g / Cs₂CO₃ / dimethylformamide / 6 h

6: 2.7 g / toluene / 0.5 h / Heating

7: 24 percent / 10percent aq. citric acid / methanol / 0.5 h / Heating

With manganese(IV) oxide; lithium aluminium tetrahydride; sodium methylate; caesium carbonate; acetic acid; citric acid; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00068a002