trans-8-chloro-1-(4-phenyl-cyclohexyl)-5-pyridin-2-yl-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene

Base Information

Chemical Name:trans-8-chloro-1-(4-phenyl-cyclohexyl)-5-pyridin-2-yl-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene
CAS No.:1337965-64-6
Molecular Formula:C₂₇H₂₆ClN₅
Molecular Weight:455.99
Hs Code.:

Synonyms:trans-8-chloro-1-(4-phenyl-cyclohexyl)-5-pyridin-2-yl-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene

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Chemical Property of trans-8-chloro-1-(4-phenyl-cyclohexyl)-5-pyridin-2-yl-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene

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Technology Process of trans-8-chloro-1-(4-phenyl-cyclohexyl)-5-pyridin-2-yl-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene

There total 12 articles about trans-8-chloro-1-(4-phenyl-cyclohexyl)-5-pyridin-2-yl-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 109-04-6
2-bromo-pyridine

: trans-8-chloro-1-(4-phenyl-cyclohexyl)-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene hydrochloride

: 1337965-64-6
trans-8-chloro-1-(4-phenyl-cyclohexyl)-5-pyridin-2-yl-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene

Guidance literature:: With cetyltrimethylammonim bromide; sodium hydroxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In water; toluene; at 90 ℃; for 18h;

Reference yield:

: 1466-73-5
trans-4-phenylcyclohexanecarboxylic acid

: 1337965-64-6
trans-8-chloro-1-(4-phenyl-cyclohexyl)-5-pyridin-2-yl-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 0 °C

1.2: 20 °C

2.1: butan-1-ol / Reflux

3.1: hydrogenchloride / 50 °C

4.1: cetyltrimethylammonim bromide; sodium hydroxide / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / toluene; water / 18 h / 90 °C

With hydrogenchloride; cetyltrimethylammonim bromide; chloroformic acid ethyl ester; triethylamine; sodium hydroxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; water; toluene; butan-1-ol;

Reference yield:

: 1226807-97-1
7-chloro-2-thioxo-1,2,3,5-tetrahydrobenzo[e][1,4]diazepine-4-carboxylic acid tert-butyl ester

: 1337965-64-6
trans-8-chloro-1-(4-phenyl-cyclohexyl)-5-pyridin-2-yl-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene

Guidance literature:: Multi-step reaction with 3 steps

1: butan-1-ol / Reflux

2: hydrogenchloride / 50 °C

3: cetyltrimethylammonim bromide; sodium hydroxide / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / toluene; water / 18 h / 90 °C

With hydrogenchloride; cetyltrimethylammonim bromide; sodium hydroxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In water; toluene; butan-1-ol;