carbonic acid 2-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yloxy]-ethyl ester 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:carbonic acid 2-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yloxy]-ethyl ester 9H-fluoren-9-ylmethyl ester
CAS No.:581060-80-2
Molecular Formula:C₄₇H₄₄N₂O₁₁
Molecular Weight:812.873
Hs Code.:

carbonic acid 2-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yloxy]-ethyl ester 9<i>H</i>-fluoren-9-ylmethyl ester

Synonyms:carbonic acid 2-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yloxy]-ethyl ester 9H-fluoren-9-ylmethyl ester

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Chemical Property of carbonic acid 2-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yloxy]-ethyl ester 9H-fluoren-9-ylmethyl ester

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Technology Process of carbonic acid 2-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yloxy]-ethyl ester 9H-fluoren-9-ylmethyl ester

There total 9 articles about carbonic acid 2-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yloxy]-ethyl ester 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: carbonic acid 2-[2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yloxy]-ethyl ester 9H-fluoren-9-ylmethyl ester

: 581060-80-2
carbonic acid 2-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yloxy]-ethyl ester 9H-fluoren-9-ylmethyl ester

Guidance literature:: With pyridine; at 20 ℃; for 3h;
DOI:10.1039/b302855k

Reference yield:

: 186839-90-7
3-[(benzyloxy)methyl]-1-(β-D-ribofuranosyl)uracil

: 581060-80-2
carbonic acid 2-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yloxy]-ethyl ester 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 91 percent / imidazole / pyridine / 7 h / 20 °C

2: 72 percent / NaH / dimethylformamide / 2 h / -5 °C

3: 86 percent / H₂ / 20 percent Pd/C / tetrahydrofuran; methanol / 20 °C

4: 76 percent / NaBH₄ / methanol; 2-methyl-propan-2-ol / 20 °C

5: 82 percent / DBU / dimethylformamide / 20 °C

6: 86 percent / pyridine / 20 °C

7: 62 percent / H₂; aq. HCl / 20 percent Pd/C / tetrahydrofuran; methanol / 20 °C

8: 54 percent / HF-pyridine / tetrahydrofuran / 20 °C

9: 80 percent / pyridine / 3 h / 20 °C

With pyridine; 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium hydride; pyridine hydrogenfluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1039/b302855k

Reference yield:

: 879872-28-3
[(2R,3R,3aR,9aR)-2-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy]-acetic acid methyl ester

: 581060-80-2
carbonic acid 2-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yloxy]-ethyl ester 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / NaBH₄ / methanol; 2-methyl-propan-2-ol / 20 °C

2: 82 percent / DBU / dimethylformamide / 20 °C

3: 86 percent / pyridine / 20 °C

4: 62 percent / H₂; aq. HCl / 20 percent Pd/C / tetrahydrofuran; methanol / 20 °C

5: 54 percent / HF-pyridine / tetrahydrofuran / 20 °C

6: 80 percent / pyridine / 3 h / 20 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; hydrogen; pyridine hydrogenfluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1039/b302855k