2-[1-(4-ethoxy-2,6-difluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl trifluoromethanesulfonate

Base Information

Chemical Name:2-[1-(4-ethoxy-2,6-difluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl trifluoromethanesulfonate
CAS No.:1429747-44-3
Molecular Formula:C₂₆H₁₉F₅N₆O₄S
Molecular Weight:606.533
Hs Code.:

Synonyms:2-[1-(4-ethoxy-2,6-difluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl trifluoromethanesulfonate

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Chemical Property of 2-[1-(4-ethoxy-2,6-difluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl trifluoromethanesulfonate

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Technology Process of 2-[1-(4-ethoxy-2,6-difluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl trifluoromethanesulfonate

There total 1 articles about 2-[1-(4-ethoxy-2,6-difluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429747-44-3
2-[1-(4-ethoxy-2,6-difluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl trifluoromethanesulfonate

Guidance literature:: With pyridine; In dichloromethane; at 3 ℃; for 45h; Inert atmosphere;

Reference yield: 20.1%

: 1429747-44-3
2-[1-(4-ethoxy-2,6-difluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl trifluoromethanesulfonate

: 1429746-19-9
2-[1-(4-ethoxy-2,6-difluorobenzyl)-1H-indazol-3-yl]-N-(pyridin-4-yl)-pyrimidin-4-amine

Guidance literature:: With triethylsilane; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In N,N-dimethyl-formamide; at 60 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1429747-44-3
2-[1-(4-ethoxy-2,6-difluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl trifluoromethanesulfonate

: 1429746-53-1
N-{2-[1-(4-ethoxy-2,6-difluorobenzyl)-1H-indazol-3-yl]pyrimidin-4-yl}-N-(pyridin-4-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylsilane; 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 18 h / 60 °C / Inert atmosphere

2: triethylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere

With triethylsilane; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;