6-AMINO-5-METHYLINDOLE

Base Information

• Chemical Name: 6-AMINO-5-METHYLINDOLE
• CAS No.: 75844-28-9
• Molecular Formula: C₈H₉N₃
• Molecular Weight: 147.18
• Hs Code.: 2933990090
• Mol file: 75844-28-9.mol

Synonyms:Indazole,6-amino-5-methyl- (2CI); 5-Methyl-6-amino-1H-indazole; 6-Amino-5-methylindazole

Chemical Property of 6-AMINO-5-METHYLINDOLE

Chemical Property:

• Melting Point: 241-242℃
• Boiling Point: 374.0±22.0 °C(Predicted)
• PKA: 15.83±0.40(Predicted)
• PSA: 54.70000
• Density: 1.295
• LogP: 2.03470
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99%, ^*data from raw suppliers

5-methyl-1H-indazol-6-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-AMINO-5-METHYLINDOLE

There total 6 articles about 6-AMINO-5-METHYLINDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-methyl-6-nitro-1H-indazole (72521-00-7) → 5-methyl-6-amino-1H-indazole (75844-28-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; Inert atmosphere;

DOI:10.1016/j.bmc.2015.11.035

Reference yield:

2,4-Xylidine (95-68-1) → 5-methyl-6-amino-1H-indazole (75844-28-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; nitric acid / Inert atmosphere

2: sodium nitrite; acetic acid / Inert atmosphere

3: hydrogen; palladium on activated charcoal / methanol / Inert atmosphere

With sulfuric acid; palladium on activated charcoal; hydrogen; nitric acid; acetic acid; sodium nitrite; In methanol;

DOI:10.1016/j.bmc.2015.11.035

Reference yield:

5-nitro-2,4-dimethylaniline (2124-47-2) → 5-methyl-6-amino-1H-indazole (75844-28-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium nitrite; acetic acid / Inert atmosphere

2: hydrogen; palladium on activated charcoal / methanol / Inert atmosphere

With palladium on activated charcoal; hydrogen; acetic acid; sodium nitrite; In methanol;

DOI:10.1016/j.bmc.2015.11.035

upstream raw materials:

5-methyl-6-nitro-1⁽²⁾H-indazole

5-methyl-6-nitro-1H-indazole

2,4-Xylidine

5-nitro-2,4-dimethylaniline

Downstream raw materials:

1,6-Dihydro-5H-pyrazolo<4,3-g>chinazolin-5-on

pyrazolo<4,3-g>quinazoline-5,7-dione

7-Amino-1,6-dihydro-5H-pyrazolo<4,3-g>chinazolin-5-on

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