methyl 3-benzyl-2-thioxo-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate

Base Information

Chemical Name:methyl 3-benzyl-2-thioxo-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate
CAS No.:360787-41-3
Molecular Formula:C₂₂H₂₂N₂O₂S
Molecular Weight:378.495
Hs Code.:

Synonyms:methyl 3-benzyl-2-thioxo-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate

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Chemical Property of methyl 3-benzyl-2-thioxo-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate

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Technology Process of methyl 3-benzyl-2-thioxo-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate

There total 10 articles about methyl 3-benzyl-2-thioxo-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 360787-37-7
methyl 3-benzyl-2-oxo-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate

: 360787-41-3
methyl 3-benzyl-2-thioxo-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate

Guidance literature:: With Lawessons reagent; In toluene; for 12h; Heating;
DOI:10.1021/jo000249z

Reference yield:

: 360787-29-7
dimethyl 3-[3-[dibenzylamino]propyl]indole-2-propanedioate

: 360787-41-3
methyl 3-benzyl-2-thioxo-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / H₂ / Pd/C / acetic acid / 3 h

2: 71 percent / toluene / 5 h / Heating

3: 76 percent / Lawesson's reagent / toluene / 12 h / Heating

With Lawessons reagent; hydrogen; palladium on activated charcoal; In acetic acid; toluene;
DOI:10.1021/jo000249z

Reference yield:

: 87400-38-2
N-benzyl-3-(1H-indol-3-yl)propan-1-amine

: 360787-41-3
methyl 3-benzyl-2-thioxo-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / NaOH / tetrahydrofuran / 3 h / 20 °C

2.1: triethylamine; tert-butyl hypochlorite / tetrahydrofuran / 0.33 h

2.2: ZnCl₂ / tetrahydrofuran / 0.08 h

2.3: 89 percent / tetrahydrofuran / -60 - 20 °C

3.1: 96 percent / HCl / methanol / 2 h / 40 °C

4.1: 71 percent / toluene / 5 h / Heating

5.1: 76 percent / Lawesson's reagent / toluene / 12 h / Heating

With Lawessons reagent; hydrogenchloride; sodium hydroxide; tert-butylhypochlorite; triethylamine; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jo000249z