(2S,3S)-3-(((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)thio)-2-(((benzyloxy)carbonyl)amino)butanoic acid

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Chemical Name:(2S,3S)-3-(((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)thio)-2-(((benzyloxy)carbonyl)amino)butanoic acid
CAS No.:1359740-86-5
Molecular Formula:C₃₄H₃₈N₂O₈S
Molecular Weight:634.75
Hs Code.:

Synonyms:(2S,3S)-3-(((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)thio)-2-(((benzyloxy)carbonyl)amino)butanoic acid

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Chemical Property of (2S,3S)-3-(((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)thio)-2-(((benzyloxy)carbonyl)amino)butanoic acid

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Technology Process of (2S,3S)-3-(((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)thio)-2-(((benzyloxy)carbonyl)amino)butanoic acid

There total 2 articles about (2S,3S)-3-(((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)thio)-2-(((benzyloxy)carbonyl)amino)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 858669-61-1
(2S,3S)-N-benzyloxycarbonyl-3-methylcysteine methyl ester

: 1359740-86-5
(2S,3S)-3-(((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)thio)-2-(((benzyloxy)carbonyl)amino)butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetra(n-butyl)ammonium hydrogensulfate; caesium carbonate / ethyl acetate / 20 °C / Inert atmosphere

2: trimethyltin(IV) hydroxide / 1,2-dichloro-ethane / 4 h / 78 °C / Inert atmosphere

With tetra(n-butyl)ammonium hydrogensulfate; caesium carbonate; trimethyltin(IV) hydroxide; In ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1021/ol2034806

Reference yield:

: 634182-11-9
(R)-β-bromo-N-(fluoren-9-ylmethoxycarbonyl)alanine tert-butyl ester

: 1359740-86-5
(2S,3S)-3-(((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)thio)-2-(((benzyloxy)carbonyl)amino)butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetra(n-butyl)ammonium hydrogensulfate; caesium carbonate / ethyl acetate / 20 °C / Inert atmosphere

2: trimethyltin(IV) hydroxide / 1,2-dichloro-ethane / 4 h / 78 °C / Inert atmosphere

With tetra(n-butyl)ammonium hydrogensulfate; caesium carbonate; trimethyltin(IV) hydroxide; In ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1021/ol2034806

Reference yield:

: 1359740-86-5
(2S,3S)-3-(((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)thio)-2-(((benzyloxy)carbonyl)amino)butanoic acid

: C₄₄H₅₉N₅O₁₁Si

: 1359740-93-4
C₇₈H₉₅N₇O₁₈SSi

Guidance literature:: With N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol2034806