2-(4-(6-bromo-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-1-methyl-3-oxopiperazine

Base Information

Chemical Name:2-(4-(6-bromo-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-1-methyl-3-oxopiperazine
CAS No.:1361940-97-7
Molecular Formula:C₁₆H₁₈BrN₅O₂
Molecular Weight:392.255
Hs Code.:

Synonyms:2-(4-(6-bromo-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-1-methyl-3-oxopiperazine

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Chemical Property of 2-(4-(6-bromo-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-1-methyl-3-oxopiperazine

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Technology Process of 2-(4-(6-bromo-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-1-methyl-3-oxopiperazine

There total 3 articles about 2-(4-(6-bromo-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-1-methyl-3-oxopiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1361940-96-6
3-(4-aminophenyl)-4-methylpiperazin-2-one

: 87486-34-8
3,5-dibromo-1-methyl-1,2-dihydropyrazin-2-one

: 1361940-97-7
2-(4-(6-bromo-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-1-methyl-3-oxopiperazine

Guidance literature:: 3-(4-aminophenyl)-4-methylpiperazin-2-one; 3,5-dibromo-1-methyl-1,2-dihydropyrazin-2-one; With caesium carbonate; In 1,4-dioxane; for 0.5h; Reflux; Inert atmosphere;

With 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; for 18h; Reflux;

Reference yield:

: 1133434-08-8
3-(4-Nitrophenyl)-5,6-dihydropyrazin-2(1H)-one

: 1361940-97-7
2-(4-(6-bromo-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-1-methyl-3-oxopiperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium cyanoborohydride; zinc(II) chloride; formaldehyd / water / 1 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride; iron / ethanol / 0.5 h / Reflux; Inert atmosphere

2.2: 20 °C

3.1: caesium carbonate / 1,4-dioxane / 0.5 h / Reflux; Inert atmosphere

3.2: 18 h / Reflux

With hydrogenchloride; formaldehyd; iron; sodium cyanoborohydride; caesium carbonate; zinc(II) chloride; In 1,4-dioxane; ethanol; water;

Reference yield:

: 1361940-95-5
4-methyl-3-(4-nitrophenyl)piperazine-2-one

: 1361940-97-7
2-(4-(6-bromo-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-1-methyl-3-oxopiperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; iron / ethanol / 0.5 h / Reflux; Inert atmosphere

1.2: 20 °C

2.1: caesium carbonate / 1,4-dioxane / 0.5 h / Reflux; Inert atmosphere

2.2: 18 h / Reflux

With hydrogenchloride; iron; caesium carbonate; In 1,4-dioxane; ethanol;