5-dimethylamino-5-[(1',4'-dioxaspiro[4.5]dec-6'-yl)methyl]-3-ethoxy-1,2-diphenyl-1,3-cyclopentadiene

Base Information

• Chemical Name: 5-dimethylamino-5-[(1',4'-dioxaspiro[4.5]dec-6'-yl)methyl]-3-ethoxy-1,2-diphenyl-1,3-cyclopentadiene
• CAS No.: 856018-33-2
• Molecular Formula: C₃₀H₃₇NO₃
• Molecular Weight: 459.629

Synonyms:5-dimethylamino-5-[(1',4'-dioxaspiro[4.5]dec-6'-yl)methyl]-3-ethoxy-1,2-diphenyl-1,3-cyclopentadiene

Chemical Property of 5-dimethylamino-5-[(1',4'-dioxaspiro[4.5]dec-6'-yl)methyl]-3-ethoxy-1,2-diphenyl-1,3-cyclopentadiene

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Technology Process of 5-dimethylamino-5-[(1',4'-dioxaspiro[4.5]dec-6'-yl)methyl]-3-ethoxy-1,2-diphenyl-1,3-cyclopentadiene

There total 1 articles about 5-dimethylamino-5-[(1',4'-dioxaspiro[4.5]dec-6'-yl)methyl]-3-ethoxy-1,2-diphenyl-1,3-cyclopentadiene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

diphenyl acetylene (501-65-5) → 5-dimethylamino-5-[(1',4'-dioxaspiro[4.5]dec-6'-yl)methyl]-3-ethoxy-1,2-diphenyl-1,3-cyclopentadiene (856018-33-2)

Guidance literature:

In pyridine; at 80 ℃; for 96h;

DOI:10.1002/ejoc.200400858

Reference yield: 63.0%

5-dimethylamino-5-[(1',4'-dioxaspiro[4.5]dec-6'-yl)methyl]-3-ethoxy-1,2-diphenyl-1,3-cyclopentadiene (856018-33-2) → (3aR,3bR,7aS,8aS)-8a-dimethylamino-3b-hydroxy-1,2-diphenyl-3b,4,5,6,7,7a,8,8a-octahydro-3aH-cyclopenta[a]inden-3-one + (3aR,3bS,7aR,8aS)-8a-dimethylamino-3b-hydroxy-1,2-diphenyl-3b,4,5,6,7,7a,8,8a-octahydro-3aH-cyclopenta[a]inden-3-one + (3aR,3bS,7aS,8aS)-8a-dimethylamino-3b-hydroxy-1,2-diphenyl-3b,4,5,6,7,7a,8,8a-octahydro-3aH-cyclopenta[a]inden-3-one

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 48h;

DOI:10.1002/ejoc.200400858

Reference yield:

5-dimethylamino-5-[(1',4'-dioxaspiro[4.5]dec-6'-yl)methyl]-3-ethoxy-1,2-diphenyl-1,3-cyclopentadiene (856018-33-2) → 8a-dimethylamino-1,2-diphenyl-3a,4,5,6,7,8,8a-heptahydrocyclopenta[a]inden-3-one

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / hydrochloric acid / dioxane / 48 h / 20 °C

2: 81 percent / pTsOH / benzene / 2 h / Heating

With hydrogenchloride; toluene-4-sulfonic acid; In 1,4-dioxane; benzene;

DOI:10.1002/ejoc.200400858

upstream raw materials:

diphenyl acetylene

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