Benzoic acid (S)-2-[(4S,5S)-2,2-dimethyl-5-((E)-2-methyl-4-trimethylsilanyl-but-1-en-3-ynyl)-[1,3]dioxolan-4-yl]-1-methyl-ethyl ester

Base Information

Chemical Name:Benzoic acid (S)-2-[(4S,5S)-2,2-dimethyl-5-((E)-2-methyl-4-trimethylsilanyl-but-1-en-3-ynyl)-[1,3]dioxolan-4-yl]-1-methyl-ethyl ester
CAS No.:863445-05-0
Molecular Formula:C₂₃H₃₂O₄Si
Molecular Weight:400.59
Hs Code.:

Synonyms:Benzoic acid (S)-2-[(4S,5S)-2,2-dimethyl-5-((E)-2-methyl-4-trimethylsilanyl-but-1-en-3-ynyl)-[1,3]dioxolan-4-yl]-1-methyl-ethyl ester

Suppliers and Price of Benzoic acid (S)-2-[(4S,5S)-2,2-dimethyl-5-((E)-2-methyl-4-trimethylsilanyl-but-1-en-3-ynyl)-[1,3]dioxolan-4-yl]-1-methyl-ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Benzoic acid (S)-2-[(4S,5S)-2,2-dimethyl-5-((E)-2-methyl-4-trimethylsilanyl-but-1-en-3-ynyl)-[1,3]dioxolan-4-yl]-1-methyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Benzoic acid (S)-2-[(4S,5S)-2,2-dimethyl-5-((E)-2-methyl-4-trimethylsilanyl-but-1-en-3-ynyl)-[1,3]dioxolan-4-yl]-1-methyl-ethyl ester

There total 10 articles about Benzoic acid (S)-2-[(4S,5S)-2,2-dimethyl-5-((E)-2-methyl-4-trimethylsilanyl-but-1-en-3-ynyl)-[1,3]dioxolan-4-yl]-1-methyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 863444-31-9
benzoic acid 2-[5-(2-iodo-propenyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-ethyl ester

: 1066-54-2
trimethylsilylacetylene

: 863445-05-0
Benzoic acid (S)-2-[(4S,5S)-2,2-dimethyl-5-((E)-2-methyl-4-trimethylsilanyl-but-1-en-3-ynyl)-[1,3]dioxolan-4-yl]-1-methyl-ethyl ester

Guidance literature:: trimethylsilylacetylene; With isopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 20 ℃; for 0.0833333h;

benzoic acid 2-[5-(2-iodo-propenyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-ethyl ester; With copper(l) iodide; isopropylamine; for 1h;
DOI:10.1039/b505980a

Reference yield:

: 863444-55-7
benzoic acid 2-(2,2-dimethyl-5-prop-1-ynyl-[1,3]dioxolan-4-yl)-1-methyl-ethyl ester

: 863445-05-0
Benzoic acid (S)-2-[(4S,5S)-2,2-dimethyl-5-((E)-2-methyl-4-trimethylsilanyl-but-1-en-3-ynyl)-[1,3]dioxolan-4-yl]-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Bu₃SnH / PdCl₂(PPh₃)2 / pentane / 0.75 h

1.2: 144 mg / I₂ / CH₂Cl₂ / 0.33 h / -78 - 20 °C

2.1: iPrNH₂ / Pd(PPh₃)4 / 0.08 h / 20 °C

2.2: 97 percent / CuI; iPrNH₂ / 1 h

With tri-n-butyl-tin hydride; isopropylamine; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In pentane; 2.2: Sonogashira coupling;
DOI:10.1039/b505980a

Reference yield:

: 863444-49-9
6-O-benzoyl-1,1-dibromo-5,7-dideoxy-3,4-O-isopropyliden-L-arabino-hept-1-ene

: 863445-05-0
Benzoic acid (S)-2-[(4S,5S)-2,2-dimethyl-5-((E)-2-methyl-4-trimethylsilanyl-but-1-en-3-ynyl)-[1,3]dioxolan-4-yl]-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 88 percent / LDA / tetrahydrofuran; hexane / 2 h / -78 °C

2.1: LDA / tetrahydrofuran; hexane / 0.05 h / -78 °C

2.2: 88 percent / HMPA / tetrahydrofuran; hexane / 2 h / -78 - -10 °C

3.1: Bu₃SnH / PdCl₂(PPh₃)2 / pentane / 0.75 h

3.2: 144 mg / I₂ / CH₂Cl₂ / 0.33 h / -78 - 20 °C

4.1: iPrNH₂ / Pd(PPh₃)4 / 0.08 h / 20 °C

4.2: 97 percent / CuI; iPrNH₂ / 1 h

With tri-n-butyl-tin hydride; isopropylamine; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; pentane; 4.2: Sonogashira coupling;
DOI:10.1039/b505980a