(R)-1-{4-((R)-1,2-dihydroxy-ethyl)-6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-ethane-1,2-diol

Base Information

Chemical Name:(R)-1-{4-((R)-1,2-dihydroxy-ethyl)-6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-ethane-1,2-diol
CAS No.:1367124-29-5
Molecular Formula:C₂₁H₂₀FNO₅
Molecular Weight:385.392
Hs Code.:

Synonyms:(R)-1-{4-((R)-1,2-dihydroxy-ethyl)-6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-ethane-1,2-diol

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Chemical Property of (R)-1-{4-((R)-1,2-dihydroxy-ethyl)-6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-ethane-1,2-diol

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Technology Process of (R)-1-{4-((R)-1,2-dihydroxy-ethyl)-6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-ethane-1,2-diol

There total 9 articles about (R)-1-{4-((R)-1,2-dihydroxy-ethyl)-6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-ethane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1367126-23-5
2-[4-(4-fluoro-phenoxy)-phenyl]-4,6-divinyl-pyridine

: 1367124-29-5
(R)-1-{4-((R)-1,2-dihydroxy-ethyl)-6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-ethane-1,2-diol

Guidance literature:: With AD-mix β; In water; tert-butyl alcohol; at 20 ℃; for 18h; Cooling with ice;

Reference yield:

: 371-41-5
4-Fluorophenol

: 1367124-29-5
(R)-1-{4-((R)-1,2-dihydroxy-ethyl)-6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-ethane-1,2-diol

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / Inert atmosphere

3.1: sulfuric acid / 1,2-dimethoxyethane; water

3.2: 0.83 h / 0 - 5 °C

3.3: 0.5 h / 0 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere

4.2: 18 h / 90 °C / Inert atmosphere

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; ethanol; water / 18 h / 80 °C

6.1: tetrabutyl ammonium fluoride / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

7.1: AD-mix β / water; tert-butyl alcohol / 18 h / 20 °C / Cooling with ice

With AD-mix β; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; sodium carbonate; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1367124-29-5
(R)-1-{4-((R)-1,2-dihydroxy-ethyl)-6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-ethane-1,2-diol

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / Inert atmosphere

3.1: sulfuric acid / 1,2-dimethoxyethane; water

3.2: 0.83 h / 0 - 5 °C

3.3: 0.5 h / 0 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere

4.2: 18 h / 90 °C / Inert atmosphere

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; ethanol; water / 18 h / 80 °C

6.1: tetrabutyl ammonium fluoride / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

7.1: AD-mix β / water; tert-butyl alcohol / 18 h / 20 °C / Cooling with ice

With AD-mix β; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; sodium carbonate; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;