(2R)-2-hydroxy-2-(N,N-diphenylcarbamoyloxymethyl)-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

Base Information

Chemical Name:(2R)-2-hydroxy-2-(N,N-diphenylcarbamoyloxymethyl)-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene
CAS No.:172937-73-4
Molecular Formula:C₄₀H₄₁NO₄Si
Molecular Weight:627.855
Hs Code.:

Synonyms:(2R)-2-hydroxy-2-(N,N-diphenylcarbamoyloxymethyl)-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

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Chemical Property of (2R)-2-hydroxy-2-(N,N-diphenylcarbamoyloxymethyl)-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

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Technology Process of (2R)-2-hydroxy-2-(N,N-diphenylcarbamoyloxymethyl)-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

There total 3 articles about (2R)-2-hydroxy-2-(N,N-diphenylcarbamoyloxymethyl)-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R)-2-hydroxy-2-hydroxymethyl-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

: 83-01-2
diphenylcarbamic chloride

: 172937-73-4
(2R)-2-hydroxy-2-(N,N-diphenylcarbamoyloxymethyl)-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

Guidance literature:: In pyridine;

Reference yield:

: 1-bromo-5-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid ethyl ester

: 172937-73-4
(2R)-2-hydroxy-2-(N,N-diphenylcarbamoyloxymethyl)-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran

2: pyridine

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2005.04.047

Reference yield:

: 172937-65-4
(1S,2R)-1,2-dihydroxy-2-ethoxycarbonyl-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

: 172937-73-4
(2R)-2-hydroxy-2-(N,N-diphenylcarbamoyloxymethyl)-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

Guidance literature:: Multi-step reaction with 3 steps

1: CBr₄; PPh₃ / CH₂Cl₂

2: LiAlH₄ / tetrahydrofuran

3: pyridine

With pyridine; lithium aluminium tetrahydride; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.04.047