10-methyl-8-phenylbenzo[5,6]chromeno[2,3-c]pyrazol-11(8H)-one

Base Information

• Chemical Name: 10-methyl-8-phenylbenzo[5,6]chromeno[2,3-c]pyrazol-11(8H)-one
• CAS No.: 30241-54-4
• Molecular Formula: C₂₁H₁₄N₂O₂
• Molecular Weight: 326.354
• Mol file: 30241-54-4.mol

Synonyms:10-methyl-8-phenylbenzo[5,6]chromeno[2,3-c]pyrazol-11(8H)-one

Chemical Property of 10-methyl-8-phenylbenzo[5,6]chromeno[2,3-c]pyrazol-11(8H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-methyl-8-phenylbenzo[5,6]chromeno[2,3-c]pyrazol-11(8H)-one

There total 3 articles about 10-methyl-8-phenylbenzo[5,6]chromeno[2,3-c]pyrazol-11(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3-methyl-5-(naphthalen-2-yloxy)-1-phenyl-1H-pyrazole-4-carbaldehyde (30241-49-7) → 10-methyl-8-phenylbenzo[5,6]chromeno[2,3-c]pyrazol-11(8H)-one (30241-54-4)

Guidance literature:

With tert.-butylhydroperoxide; 1,3-dibutyl-1H-benzo[d]-[1,2,3]triazol-3-ium bromide; In water; at 120 ℃; for 24h; Green chemistry;

DOI:10.1021/acs.orglett.5b00033

Reference yield:

5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole (947-95-5) → 10-methyl-8-phenylbenzo[5,6]chromeno[2,3-c]pyrazol-11(8H)-one (30241-54-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 90 °C

2: tert.-butylhydroperoxide; 1,3-dibutyl-1H-benzo[d]-[1,2,3]triazol-3-ium bromide / water / 24 h / 120 °C / Green chemistry

With tert.-butylhydroperoxide; 1,3-dibutyl-1H-benzo[d]-[1,2,3]triazol-3-ium bromide; potassium carbonate; In water; N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.5b00033

Reference yield:

3-methyl-5-naphthalen-2-yloxy-1-phenyl-1H-pyrazole-4-carboxylic acid (30241-52-2) → 10-methyl-8-phenylbenzo[5,6]chromeno[2,3-c]pyrazol-11(8H)-one (30241-54-4)

Guidance literature:

With PPA;

DOI:10.1007/BF00771349

upstream raw materials:

3-methyl-5-naphthalen-2-yloxy-1-phenyl-1H-pyrazole-4-carboxylic acid

5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole

3-methyl-5-(naphthalen-2-yloxy)-1-phenyl-1H-pyrazole-4-carbaldehyde