(R)-N-benzyloxycarbonyl-2-chloromethylalanine-L-threonine methyl ester

Base Information

Chemical Name:(R)-N-benzyloxycarbonyl-2-chloromethylalanine-L-threonine methyl ester
CAS No.:519020-77-0
Molecular Formula:C₁₇H₂₃ClN₂O₆
Molecular Weight:386.832
Hs Code.:

Synonyms:(R)-N-benzyloxycarbonyl-2-chloromethylalanine-L-threonine methyl ester

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Chemical Property of (R)-N-benzyloxycarbonyl-2-chloromethylalanine-L-threonine methyl ester

Chemical Property:

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Technology Process of (R)-N-benzyloxycarbonyl-2-chloromethylalanine-L-threonine methyl ester

There total 3 articles about (R)-N-benzyloxycarbonyl-2-chloromethylalanine-L-threonine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 39994-75-7
L-threonine methyl ester hydrochloride

: 519020-76-9
(R)-2-benzyloxycarbonylamino-3-chloro-2-methylpropionic acid

: 519020-77-0
(R)-N-benzyloxycarbonyl-2-chloromethylalanine-L-threonine methyl ester

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; at 0 - 20 ℃; for 24h;

Reference yield:

: 135923-86-3,135923-87-4,143564-89-0
(2R,4R)-3-<(Benzyloxy)carbonyl>-4-methyl-2-phenyl-1,3-oxazolidin-5-one

: 519020-77-0
(R)-N-benzyloxycarbonyl-2-chloromethylalanine-L-threonine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / DMPU; LHMDS / tetrahydrofuran / 1.5 h / -78 °C

2: 84 percent / LiOH; H₂O / tetrahydrofuran / 6 h / 20 °C

3: 88 percent / DIPEA; DMAP; PyBroP / CH₂Cl₂ / 24 h / 0 - 20 °C

With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hydroxide; water; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

Reference yield:

: 519020-70-3
(R)-4-chloromethyl-4-methyl-5-oxo-2-phenyloxazolidine-3-carboxylic acid benzyl ester

: 519020-77-0
(R)-N-benzyloxycarbonyl-2-chloromethylalanine-L-threonine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / LiOH; H₂O / tetrahydrofuran / 6 h / 20 °C

2: 88 percent / DIPEA; DMAP; PyBroP / CH₂Cl₂ / 24 h / 0 - 20 °C

With dmap; lithium hydroxide; water; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; dichloromethane;