S,S-dimethyl-N-(3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl)sulfoximine

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Chemical Name:S,S-dimethyl-N-(3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl)sulfoximine
CAS No.:1610449-24-5
Molecular Formula:C₃₆H₃₇N₉O₄S
Molecular Weight:691.814
Hs Code.:

Synonyms:S,S-dimethyl-N-(3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl)sulfoximine

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Chemical Property of S,S-dimethyl-N-(3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl)sulfoximine

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Technology Process of S,S-dimethyl-N-(3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl)sulfoximine

There total 5 articles about S,S-dimethyl-N-(3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl)sulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610450-04-8
3-[[dimethyl(oxo)-λ6-sulfanylidene]amino]aniline

: 1610450-03-7
1-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)-3-(4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)urea

: 1610449-24-5
S,S-dimethyl-N-(3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl)sulfoximine

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; at 70 ℃; for 18h;

Reference yield:

: 56158-14-6
S,S-dimethyl-N-(3-nitrophenyl)-sulfoximine

: 1610449-24-5
S,S-dimethyl-N-(3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl)sulfoximine

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 5 h

2: toluene-4-sulfonic acid / tetrahydrofuran; N,N-dimethyl-formamide / 18 h / 70 °C

With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 99-09-2
3-nitro-aniline

: 1610449-24-5
S,S-dimethyl-N-(3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl)sulfoximine

Guidance literature:: Multi-step reaction with 3 steps

1.1: tert-butylhypochlorite / dichloromethane / 6 h / -60 - -50 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 5 h

3.1: toluene-4-sulfonic acid / tetrahydrofuran; N,N-dimethyl-formamide / 18 h / 70 °C

With tert-butylhypochlorite; palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;