4-Pyridinecarboxamide,N-[4-(1-aminoethyl)cyclohexyl]-,trans-(+)-(9CI)

Base Information

Chemical Name:4-Pyridinecarboxamide,N-[4-(1-aminoethyl)cyclohexyl]-,trans-(+)-(9CI)
CAS No.:742043-06-7
Molecular Formula:C₁₄H₂₁N₃O
Molecular Weight:247.34
Hs Code.:
Mol file:742043-06-7.mol

Synonyms:Cyclohexanecarboxamide,4-(1-aminoethyl)-N-4-pyridinyl-, [4(R)-trans]-; (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)cyclohexanecarboamide;Y 27632

Suppliers and Price of 4-Pyridinecarboxamide,N-[4-(1-aminoethyl)cyclohexyl]-,trans-(+)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 4-Pyridinecarboxamide,N-[4-(1-aminoethyl)cyclohexyl]-,trans-(+)-(9CI)

Chemical Property:

Vapor Pressure:9.74E-09mmHg at 25°C
Refractive Index:1.578
Boiling Point:462.6°C at 760 mmHg
Flash Point:233.6°C
Density:1.136g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of 4-Pyridinecarboxamide,N-[4-(1-aminoethyl)cyclohexyl]-,trans-(+)-(9CI)

There total 10 articles about 4-Pyridinecarboxamide,N-[4-(1-aminoethyl)cyclohexyl]-,trans-(+)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 671816-04-9
trans-tert-butyl (R)-1-[4-(pyridin-4-ylcarbamoyl)cyclohexyl]ethylcarbamate

: 742043-06-7
R-(+)-trans-4-(1-aminoethyl)-N-(4-pyridyl)-cyclohexanecarboxamide

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1318865-17-6
trans-(R)-4-(1-aminoethyl)cyclohexanecarboxylic acid methyl ester

: 742043-06-7
R-(+)-trans-4-(1-aminoethyl)-N-(4-pyridyl)-cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 3 h / Inert atmosphere

2: sodium hydroxide; methanol / 3 h

3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: hydrogenchloride / dichloromethane; diethyl ether / 0 - 20 °C

With hydrogenchloride; methanol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: (1R,4r)-methyl 4-((R)-1-((tert-butoxycarbonyl)amino)ethyl)cyclohexanecarboxylate

: 742043-06-7
R-(+)-trans-4-(1-aminoethyl)-N-(4-pyridyl)-cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; methanol / 3 h

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: hydrogenchloride / dichloromethane; diethyl ether / 0 - 20 °C

With hydrogenchloride; methanol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;