N-hydroxy-4-((1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-9-yl)methyl)benzamide trifluoroacetate

Base Information

• Chemical Name: N-hydroxy-4-((1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-9-yl)methyl)benzamide trifluoroacetate
• CAS No.: 1354547-65-1
• Molecular Formula: C₂HF₃O₂*C₁₉H₁₉N₃O₂
• Molecular Weight: 435.403
• Mol file: 1354547-65-1.mol

Synonyms:N-hydroxy-4-((1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-9-yl)methyl)benzamide trifluoroacetate

Chemical Property of N-hydroxy-4-((1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-9-yl)methyl)benzamide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-hydroxy-4-((1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-9-yl)methyl)benzamide trifluoroacetate

There total 5 articles about N-hydroxy-4-((1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-9-yl)methyl)benzamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

methyl 4-((3,4-dihydro-1H-pyrido[3,4-b]indol-9(2H)-yl)methyl)benzoate (783293-89-0) + trifluoroacetic acid (76-05-1) → N-hydroxy-4-((1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-9-yl)methyl)benzamide trifluoroacetate (1354547-65-1)

Guidance literature:

methyl 4-((3,4-dihydro-1H-pyrido[3,4-b]indol-9(2H)-yl)methyl)benzoate; With hydroxylamine hydrochloride; sodium methylate; In methanol; N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm200773h

Reference yield:

tert-butyl 9-(4-(hydroxycarbamoyl)benzyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate + trifluoroacetic acid (76-05-1) → N-hydroxy-4-((1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-9-yl)methyl)benzamide trifluoroacetate (1354547-65-1)

Guidance literature:

tert-butyl 9-(4-(hydroxycarbamoyl)benzyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate; With hydrogenchloride; In 1,4-dioxane; at 22 ℃; for 4h;

trifluoroacetic acid;

DOI:10.1021/acs.jmedchem.8b01936

Reference yield:

tert-butyl 9-(4-(methoxycarbonyl)benzyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate (1354547-63-9) → N-hydroxy-4-((1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-9-yl)methyl)benzamide trifluoroacetate (1354547-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 30 °C

2: hydroxylamine hydrochloride; sodium methylate / methanol; N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With hydroxylamine hydrochloride; sodium methylate; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm200773h

upstream raw materials:

tert-butyl 9-(4-(methoxycarbonyl)benzyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate

methyl 4-((3,4-dihydro-1H-pyrido[3,4-b]indol-9(2H)-yl)methyl)benzoate

trifluoroacetic acid

tetrahydrobetacarboline

Downstream raw materials:

N-hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-β-carbolin-9-ylmethyl)benzamide trifluoroacetic acid salt