ethyl 4-((2S)-2-([(benzyloxy)carbonyl]amino)-5-tert-butoxy-5-oxopentanoyl)piperazine-1-carboxylate

Base Information

Chemical Name:ethyl 4-((2S)-2-([(benzyloxy)carbonyl]amino)-5-tert-butoxy-5-oxopentanoyl)piperazine-1-carboxylate
CAS No.:710335-29-8
Molecular Formula:C₂₄H₃₅N₃O₇
Molecular Weight:477.558
Hs Code.:

Synonyms:ethyl 4-((2S)-2-([(benzyloxy)carbonyl]amino)-5-tert-butoxy-5-oxopentanoyl)piperazine-1-carboxylate

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Chemical Property of ethyl 4-((2S)-2-([(benzyloxy)carbonyl]amino)-5-tert-butoxy-5-oxopentanoyl)piperazine-1-carboxylate

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Technology Process of ethyl 4-((2S)-2-([(benzyloxy)carbonyl]amino)-5-tert-butoxy-5-oxopentanoyl)piperazine-1-carboxylate

There total 1 articles about ethyl 4-((2S)-2-([(benzyloxy)carbonyl]amino)-5-tert-butoxy-5-oxopentanoyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 120-43-4
4-ethoxycarbonylpiperazine

: 3886-08-6
5-tert-butyl N-benzyloxycarbonyl-L-glutamate

: 710335-29-8
ethyl 4-((2S)-2-([(benzyloxy)carbonyl]amino)-5-tert-butoxy-5-oxopentanoyl)piperazine-1-carboxylate

Guidance literature:: 5-tert-butyl N-benzyloxycarbonyl-L-glutamate; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 5 ℃;

4-ethoxycarbonylpiperazine; In dichloromethane; at 5 - 20 ℃;
DOI:10.1021/jm901518t

Reference yield:

: 710335-29-8
ethyl 4-((2S)-2-([(benzyloxy)carbonyl]amino)-5-tert-butoxy-5-oxopentanoyl)piperazine-1-carboxylate

: 1073553-81-7
4-{(S)-2-[(4-benzyloxycarbonylmethoxy-7-methyl-quinoline-2-carbonyl)-amino]-4-tert-butoxycarbonyl-butyryl}-piperazine-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium on activated charcoal / ethanol / 16 h / 3000.3 Torr

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 2 h

With hydrogen; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 710335-29-8
ethyl 4-((2S)-2-([(benzyloxy)carbonyl]amino)-5-tert-butoxy-5-oxopentanoyl)piperazine-1-carboxylate

: C₃₄H₄₁N₅O₇

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / ethanol / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With palladium on activated charcoal; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2014.06.070