Benzoic acid (2R,3S,5R)-3-(diphenyl-phosphinoyloxymethoxy)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester

Base Information

Chemical Name:Benzoic acid (2R,3S,5R)-3-(diphenyl-phosphinoyloxymethoxy)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester
CAS No.:215248-56-9
Molecular Formula:C₃₄H₃₄N₅O₈P
Molecular Weight:671.646
Hs Code.:

Benzoic acid (2R,3S,5R)-3-(diphenyl-phosphinoyloxymethoxy)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester

Synonyms:Benzoic acid (2R,3S,5R)-3-(diphenyl-phosphinoyloxymethoxy)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester

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Chemical Property of Benzoic acid (2R,3S,5R)-3-(diphenyl-phosphinoyloxymethoxy)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester

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Technology Process of Benzoic acid (2R,3S,5R)-3-(diphenyl-phosphinoyloxymethoxy)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester

There total 1 articles about Benzoic acid (2R,3S,5R)-3-(diphenyl-phosphinoyloxymethoxy)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1707-03-5
diphenyl-phosphinic acid

: 139433-04-8
Benzoic acid (2R,3S,5R)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-3-methylsulfanylmethoxy-tetrahydro-furan-2-ylmethyl ester

: 215248-56-9
Benzoic acid (2R,3S,5R)-3-(diphenyl-phosphinoyloxymethoxy)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: With N-iodo-succinimide; In diethyl ether; dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1021/jm970766i

Reference yield:

: 215248-56-9
Benzoic acid (2R,3S,5R)-3-(diphenyl-phosphinoyloxymethoxy)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester

: 215248-62-7
N-(9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2R,3S,5R)-3-hydroxy-5-(4-hydroxy-5-methyl-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethoxy]-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Guidance literature:: Multi-step reaction with 3 steps

1: trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 0.5 h / Ambient temperature

2: aq. KOH / methanol; dioxane / 0.5 h / 0 °C

3: pyridine / Ambient temperature

With pyridine; potassium hydroxide; trimethylsilyl trifluoromethanesulfonate; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm970766i

Reference yield:

: 215248-56-9
Benzoic acid (2R,3S,5R)-3-(diphenyl-phosphinoyloxymethoxy)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester

: C₅₅H₆₈N₉O₁₃P

Guidance literature:: Multi-step reaction with 4 steps

1: trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 0.5 h / Ambient temperature

2: aq. KOH / methanol; dioxane / 0.5 h / 0 °C

3: pyridine / Ambient temperature

4: 18 percent / N,N-diisopropylethylamine / CH₂Cl₂ / a) 0 deg C, 30 min, b) RT, 1 h

With pyridine; potassium hydroxide; trimethylsilyl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm970766i