6-chloro-3,4-dihydro-3-(2-morpholinoethyl)-4-phenyl-2-trifluoromethylquinazoline

Base Information

Chemical Name:6-chloro-3,4-dihydro-3-(2-morpholinoethyl)-4-phenyl-2-trifluoromethylquinazoline
CAS No.:80171-00-2
Molecular Formula:C₂₁H₂₁ClF₃N₃O
Molecular Weight:423.865
Hs Code.:

Synonyms:6-chloro-3,4-dihydro-3-(2-morpholinoethyl)-4-phenyl-2-trifluoromethylquinazoline

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Chemical Property of 6-chloro-3,4-dihydro-3-(2-morpholinoethyl)-4-phenyl-2-trifluoromethylquinazoline

Chemical Property:

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Technology Process of 6-chloro-3,4-dihydro-3-(2-morpholinoethyl)-4-phenyl-2-trifluoromethylquinazoline

There total 7 articles about 6-chloro-3,4-dihydro-3-(2-morpholinoethyl)-4-phenyl-2-trifluoromethylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 80171-10-4
syn-5-chloro-2-trifluoroacetamidobenzophenone 3(2-morpholinoethyl)imine

: 80171-00-2
6-chloro-3,4-dihydro-3-(2-morpholinoethyl)-4-phenyl-2-trifluoromethylquinazoline

Guidance literature:: With sodium tetrahydroborate; In N,N-dimethyl-formamide; for 3h; Ambient temperature;
DOI:10.1248/cpb.29.2135

Reference yield:

: 26381-66-8
5-chloro-2-trichloroacetylaminobenzophenone

: 80171-00-2
6-chloro-3,4-dihydro-3-(2-morpholinoethyl)-4-phenyl-2-trifluoromethylquinazoline

Guidance literature:: Multi-step reaction with 4 steps

1: 16 percent / ethanol / 3 h / 60 °C

2: 30 percent / TiCl₄ / benzene

3: 61 percent / triethylamine / tetrahydrofuran / 2 h / Ambient temperature

4: 87 percent / NaBH₄ / dimethylformamide / 3 h / Ambient temperature

With sodium tetrahydroborate; titanium tetrachloride; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.29.2135

Reference yield:

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 80171-00-2
6-chloro-3,4-dihydro-3-(2-morpholinoethyl)-4-phenyl-2-trifluoromethylquinazoline

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / dimethylsulfoxide / 24 h / Ambient temperature

2: 87 percent / NaBH₄ / dimethylformamide / 3 h / Ambient temperature

With sodium tetrahydroborate; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.29.2135