5'-O-(4,4'-dimethoxytrityl)-N⁴-[2-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)ethyl]-2'-deoxycytidine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-N⁴-[2-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)ethyl]-2'-deoxycytidine
• CAS No.: 776297-93-9
• Molecular Formula: C₄₈H₆₂N₆O₁₃
• Molecular Weight: 931.053

Synonyms:5'-O-(4,4'-dimethoxytrityl)-N⁴-[2-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)ethyl]-2'-deoxycytidine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-N⁴-[2-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)ethyl]-2'-deoxycytidine

Chemical Property:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-N⁴-[2-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)ethyl]-2'-deoxycytidine

There total 3 articles about 5'-O-(4,4'-dimethoxytrityl)-N⁴-[2-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)ethyl]-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{[2-(bis-ethoxycarbonylmethyl-amino)-ethyl]-ethoxycarbonylmethyl-amino}-acetic acid (90359-20-9) → 5'-O-(4,4'-dimethoxytrityl)-N4-[2-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)ethyl]-2'-deoxycytidine (776297-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / tetrahydrofuran / 0.33 h / -15 °C

2: 290 mg / tetrahydrofuran / 18 h / 4 °C

With 4-methyl-morpholine; In tetrahydrofuran;

DOI:10.1055/s-2004-829143

Reference yield:

N4-(2-aminoethyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine (271790-84-2) + [[2-(bis-ethoxycarbonylmethyl-amino)-ethyl]-(2-isobutoxycarbonyloxy-2-oxo-ethyl)-amino]-acetic acid ethyl ester → 5'-O-(4,4'-dimethoxytrityl)-N4-[2-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)ethyl]-2'-deoxycytidine (776297-93-9)

Guidance literature:

In tetrahydrofuran; at 4 ℃; for 18h;

DOI:10.1055/s-2004-829143

Reference yield:

5'-O-(4,4'-dimethoxytrityl)-4-thio-2'-deoxyuridine → 5'-O-(4,4'-dimethoxytrityl)-N4-[2-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)ethyl]-2'-deoxycytidine (776297-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / ethanol / 18 h / 60 °C

2: 290 mg / tetrahydrofuran / 18 h / 4 °C

In tetrahydrofuran; ethanol;

DOI:10.1055/s-2004-829143

upstream raw materials:

N⁴-(2-aminoethyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

{[2-(bis-ethoxycarbonylmethyl-amino)-ethyl]-ethoxycarbonylmethyl-amino}-acetic acid

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