N-methyl-5-((2-methyl-5-nitrophenylamino)methyl)-2-(methylthio)pyrimidin-4-amine

Base Information

• Chemical Name: N-methyl-5-((2-methyl-5-nitrophenylamino)methyl)-2-(methylthio)pyrimidin-4-amine
• CAS No.: 1237750-48-9
• Molecular Formula: C₁₄H₁₇N₅O₂S
• Molecular Weight: 319.387

Synonyms:N-methyl-5-((2-methyl-5-nitrophenylamino)methyl)-2-(methylthio)pyrimidin-4-amine

Chemical Property of N-methyl-5-((2-methyl-5-nitrophenylamino)methyl)-2-(methylthio)pyrimidin-4-amine

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Technology Process of N-methyl-5-((2-methyl-5-nitrophenylamino)methyl)-2-(methylthio)pyrimidin-4-amine

There total 1 articles about N-methyl-5-((2-methyl-5-nitrophenylamino)methyl)-2-(methylthio)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

4-methylamino-2-methylthiopyrimidine-5-carboxaldehyde (185040-32-8) + 2-methyl-5-nitroaniline (99-55-8) → N-methyl-5-((2-methyl-5-nitrophenylamino)methyl)-2-(methylthio)pyrimidin-4-amine (1237750-48-9)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃;

DOI:10.1021/jm901808w

Reference yield: 78.0%

bis(trichloromethyl) carbonate (32315-10-9) + N-methyl-5-((2-methyl-5-nitrophenylamino)methyl)-2-(methylthio)pyrimidin-4-amine (1237750-48-9) → 1-methyl-3-(2-methyl-5-nitrophenyl)-7-(methylthio)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (1237750-49-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 0 - 110 ℃;

DOI:10.1021/jm901808w

upstream raw materials:

4-methylamino-2-methylthiopyrimidine-5-carboxaldehyde

2-methyl-5-nitroaniline

Downstream raw materials:

1-methyl-3-(2-methyl-5-nitrophenyl)-7-(methylthio)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

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