Ethyl (8-benzyloxy-2-ethyl-3-(m-trifluoromethylbenzoyl)indolizin-1-yl)carboxylate

Base Information

Chemical Name:Ethyl (8-benzyloxy-2-ethyl-3-(m-trifluoromethylbenzoyl)indolizin-1-yl)carboxylate
CAS No.:177558-69-9
Molecular Formula:C₂₈H₂₄F₃NO₄
Molecular Weight:495.498
Hs Code.:

Synonyms:Ethyl (8-benzyloxy-2-ethyl-3-(m-trifluoromethylbenzoyl)indolizin-1-yl)carboxylate

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Chemical Property of Ethyl (8-benzyloxy-2-ethyl-3-(m-trifluoromethylbenzoyl)indolizin-1-yl)carboxylate

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Technology Process of Ethyl (8-benzyloxy-2-ethyl-3-(m-trifluoromethylbenzoyl)indolizin-1-yl)carboxylate

There total 5 articles about Ethyl (8-benzyloxy-2-ethyl-3-(m-trifluoromethylbenzoyl)indolizin-1-yl)carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 2251-65-2
3-(Trifluoromethyl)benzoyl chloride

: 177558-64-4
Ethyl (8-Benzyloxy-2-ethylindolizin-1-yl)carboxylate

: 177558-69-9
Ethyl (8-benzyloxy-2-ethyl-3-(m-trifluoromethylbenzoyl)indolizin-1-yl)carboxylate

Guidance literature:: With triethylamine; at 90 ℃;
DOI:10.1021/jm960395q

Reference yield: 82.0%

: 177558-69-9
Ethyl (8-benzyloxy-2-ethyl-3-(m-trifluoromethylbenzoyl)indolizin-1-yl)carboxylate

Guidance literature:

Reference yield:

: 2584-12-5
ethyl 3-hydroxy-2-pyridineacetate

: 177558-69-9
Ethyl (8-benzyloxy-2-ethyl-3-(m-trifluoromethylbenzoyl)indolizin-1-yl)carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 60percent NaH / 1.) DMF, 0 deg C, 50 min, 2.) DMF, overnight

2: 92 percent / NaHCO₃ / butan-2-one / 24 h / Heating

3: 82 percent / Et₃N / 90 °C

With sodium hydride; sodium hydrogencarbonate; triethylamine; In butanone;
DOI:10.1021/jm960395q