(R)-tert-butyl 8-(1-(6-(benzylthio)-5-fluoro-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 8-(1-(6-(benzylthio)-5-fluoro-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1607486-18-9
Molecular Formula:C₃₀H₃₁FN₂O₄S
Molecular Weight:534.652
Hs Code.:

Synonyms:(R)-tert-butyl 8-(1-(6-(benzylthio)-5-fluoro-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of (R)-tert-butyl 8-(1-(6-(benzylthio)-5-fluoro-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Technology Process of (R)-tert-butyl 8-(1-(6-(benzylthio)-5-fluoro-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 8 articles about (R)-tert-butyl 8-(1-(6-(benzylthio)-5-fluoro-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 878798-87-9
2-(tert-butoxycarbonyl)-1,2,3 ,4-tetrahydroisoquinoline-8-carboxylic acid

: 1607486-18-9
(R)-tert-butyl 8-(1-(6-(benzylthio)-5-fluoro-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / tetrahydrofuran / 20 °C

2: tetrahydrofuran / 4 h / 0 °C

3: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; borane-THF / tetrahydrofuran / 0.83 h

4: tributylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 0 °C

With borane-THF; tributylphosphine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; diethylazodicarboxylate; In tetrahydrofuran;

Reference yield:

: 1432514-57-2
tert-butyl 8-[(1S)-1-hydroxyethyl]-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1607486-17-8
6-(benzylthio)-5-fluorobenzo[d]oxazol-2(3H)-one

: 1607486-18-9
(R)-tert-butyl 8-(1-(6-(benzylthio)-5-fluoro-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With tributylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 ℃; for 2h;

Reference yield:

: 167415-27-2
1-bromo-2,5-difluoro-4-nitrobenzene

: 1607486-18-9
(R)-tert-butyl 8-(1-(6-(benzylthio)-5-fluoro-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; caesium carbonate / N,N-dimethyl-formamide / 3.5 h / 70 °C / Sealed tube

2: tin(II) chloride dihdyrate; hydrogenchloride / water / 1.5 h / 90 °C / Sealed tube

3: tetrahydrofuran / 18 h / 70 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 2 h / 120 °C / Sealed tube

5: tributylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 0 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tin(II) chloride dihdyrate; tributylphosphine; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;