N-[5-[6-(2-fluorophenyl)imidazo[1,2-a]pyrazin-2-yl]-2-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide

Base Information

Chemical Name:N-[5-[6-(2-fluorophenyl)imidazo[1,2-a]pyrazin-2-yl]-2-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide
CAS No.:1383618-58-3
Molecular Formula:C₂₄H₂₀F₄N₄O
Molecular Weight:456.443
Hs Code.:

Synonyms:N-[5-[6-(2-fluorophenyl)imidazo[1,2-a]pyrazin-2-yl]-2-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide

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Chemical Property of N-[5-[6-(2-fluorophenyl)imidazo[1,2-a]pyrazin-2-yl]-2-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide

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Technology Process of N-[5-[6-(2-fluorophenyl)imidazo[1,2-a]pyrazin-2-yl]-2-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide

There total 5 articles about N-[5-[6-(2-fluorophenyl)imidazo[1,2-a]pyrazin-2-yl]-2-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1383618-57-2
N-[5-(6-chloroimidazo[1,2-a]pyrazin-2-yl)-2-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide

: 1993-03-9
o-fluorophenylboronic acid

: 1383618-58-3
N-[5-[6-(2-fluorophenyl)imidazo[1,2-a]pyrazin-2-yl]-2-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; isopropyl alcohol; at 70 ℃; for 16h;

Reference yield:

: 116965-16-3
3-nitro-4-(trifluoromethyl)benzoic acid

: 1383618-58-3
N-[5-[6-(2-fluorophenyl)imidazo[1,2-a]pyrazin-2-yl]-2-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 16 h / 95 °C

1.2: 2 h / 20 °C

1.3: 0 °C

2.1: acetonitrile / 16 h / 100 °C

3.1: acetic acid; iron / ethanol / 2 h / 80 °C

4.1: acetonitrile / 0.33 h / 80 °C

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / isopropyl alcohol; water / 16 h / 70 °C

With thionyl chloride; iron; sodium carbonate; acetic acid; bis-triphenylphosphine-palladium(II) chloride; In ethanol; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 1383625-18-0
5-(6-chloroimidazo[1,2-a]pyrazin-2-yl)-2-(trifluoromethyl)aniline

: 1383618-58-3
N-[5-[6-(2-fluorophenyl)imidazo[1,2-a]pyrazin-2-yl]-2-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 0.33 h / 80 °C

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / isopropyl alcohol; water / 16 h / 70 °C

With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; isopropyl alcohol; acetonitrile;