2,3-Dihydro-N-<4-(1,1-dimethylethyl)phenylmethyl>-N,2-dimethyl-7-benzofurancarboxamid

Base Information

• Chemical Name: 2,3-Dihydro-N-<4-(1,1-dimethylethyl)phenylmethyl>-N,2-dimethyl-7-benzofurancarboxamid
• CAS No.: 149530-57-4
• Molecular Formula: C₂₂H₂₇NO₂
• Molecular Weight: 337.462
• Mol file: 149530-57-4.mol

Synonyms:2,3-Dihydro-N-<4-(1,1-dimethylethyl)phenylmethyl>-N,2-dimethyl-7-benzofurancarboxamid

Chemical Property of 2,3-Dihydro-N-<4-(1,1-dimethylethyl)phenylmethyl>-N,2-dimethyl-7-benzofurancarboxamid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-Dihydro-N-<4-(1,1-dimethylethyl)phenylmethyl>-N,2-dimethyl-7-benzofurancarboxamid

There total 2 articles about 2,3-Dihydro-N-<4-(1,1-dimethylethyl)phenylmethyl>-N,2-dimethyl-7-benzofurancarboxamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-2,3-dihydrobenzo[b]furan-7-carboxylic acid (31457-03-1) → 2,3-Dihydro-N-<4-(1,1-dimethylethyl)phenylmethyl>-N,2-dimethyl-7-benzofurancarboxamid (149530-57-4)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / toluene / 3 h / Heating

2: triethylamine / toluene / 1 h / Ambient temperature

With thionyl chloride; triethylamine; In toluene;

DOI:10.1002/ardp.19933260608

Reference yield:

2-methyl-2,3-dihydro-benzofuran-7-carbonyl chloride (103261-01-4) + N-4-(1,1-Dimethylethyl)-N-methyl-benzolmethanamin hydrochlorid (101846-35-9) → 2,3-Dihydro-N-<4-(1,1-dimethylethyl)phenylmethyl>-N,2-dimethyl-7-benzofurancarboxamid (149530-57-4)

Guidance literature:

With triethylamine; In toluene; for 1h; Yield given; Ambient temperature;

DOI:10.1002/ardp.19933260608

Reference yield: 72.0%

2,3-Dihydro-N-<4-(1,1-dimethylethyl)phenylmethyl>-N,2-dimethyl-7-benzofurancarboxamid (149530-57-4) → 2,3-Dihydro-N-<4-(1,1-dimethylethyl)phenylmethyl>-N,2-dimethyl-7-benzofuranmethanamin-Hydrochlorid

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; for 1h; Ambient temperature;

DOI:10.1002/ardp.19933260608

upstream raw materials:

2-methyl-2,3-dihydro-benzofuran-7-carbonyl chloride

N-4-(1,1-Dimethylethyl)-N-methyl-benzolmethanamin hydrochlorid

2-methyl-2,3-dihydrobenzo[b]furan-7-carboxylic acid