Technology Process of 7α-[9-(4-methylphenylsulfonyloxy)nonyl]-3-O-methoxymethylestra-1,3,5(10)-triene-3,16β,17β-triol
There total 12 articles about 7α-[9-(4-methylphenylsulfonyloxy)nonyl]-3-O-methoxymethylestra-1,3,5(10)-triene-3,16β,17β-triol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dmap;
In
dichloromethane;
at 0 - 20 ℃;
for 15h;
DOI:10.1039/b205571f
- Guidance literature:
-
Multi-step reaction with 12 steps
1.1: 95 percent / imidazole / tetrahydrofuran / 2 h / 20 °C
2.1: Mg / tetrahydrofuran / 2 h / Heating
2.2: 37 percent / CuI / tetrahydrofuran / 0.67 h
3.1: 81 percent / pyridinium chlorochromate / CH2Cl2 / 2 h / 0 - 20 °C
4.1: aq. AcOH / tetrahydrofuran / 50 °C
5.1: 2.28 g / N,N-diisopropylethylamine / CH2Cl2 / 0.5 h / 0 °C
6.1: 68 percent / CuBr2; LiBr / acetonitrile / 0.5 h / Heating
7.1: 66 percent / H2SO4 / 4 h / Heating
8.1: 81 percent / Pb(OAc)4 / acetic acid / 3.5 h
9.1: Li(t-BuO)3AlH / tetrahydrofuran / 1 h
10.1: 0.64 g / aq. K2CO3 / methanol / 2 h / 20 °C
11.1: 91 percent / NaH / tetrahydrofuran / 1 h
12.1: 62 percent / DMAP / CH2Cl2 / 15 h / 0 - 20 °C
With
1H-imidazole; lead(IV) acetate; dmap; sulfuric acid; sodium hydride; potassium carbonate; magnesium; acetic acid; lithium tri-t-butoxyaluminum hydride; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; lithium bromide; copper(ll) bromide;
In
tetrahydrofuran; methanol; dichloromethane; acetic acid; acetonitrile;
DOI:10.1039/b205571f
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: Mg / tetrahydrofuran / 2 h / Heating
1.2: 37 percent / CuI / tetrahydrofuran / 0.67 h
2.1: 81 percent / pyridinium chlorochromate / CH2Cl2 / 2 h / 0 - 20 °C
3.1: aq. AcOH / tetrahydrofuran / 50 °C
4.1: 2.28 g / N,N-diisopropylethylamine / CH2Cl2 / 0.5 h / 0 °C
5.1: 68 percent / CuBr2; LiBr / acetonitrile / 0.5 h / Heating
6.1: 66 percent / H2SO4 / 4 h / Heating
7.1: 81 percent / Pb(OAc)4 / acetic acid / 3.5 h
8.1: Li(t-BuO)3AlH / tetrahydrofuran / 1 h
9.1: 0.64 g / aq. K2CO3 / methanol / 2 h / 20 °C
10.1: 91 percent / NaH / tetrahydrofuran / 1 h
11.1: 62 percent / DMAP / CH2Cl2 / 15 h / 0 - 20 °C
With
lead(IV) acetate; dmap; sulfuric acid; sodium hydride; potassium carbonate; magnesium; acetic acid; lithium tri-t-butoxyaluminum hydride; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; lithium bromide; copper(ll) bromide;
In
tetrahydrofuran; methanol; dichloromethane; acetic acid; acetonitrile;
DOI:10.1039/b205571f
