Benzo[1,3]dioxol-5-yl-[(3S,4R,5S)-5-benzo[1,3]dioxol-5-yl-4-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-methanone

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Chemical Name:Benzo[1,3]dioxol-5-yl-[(3S,4R,5S)-5-benzo[1,3]dioxol-5-yl-4-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-methanone
CAS No.:195321-33-6
Molecular Formula:C₃₆H₃₆O₇Si
Molecular Weight:608.763
Hs Code.:

Synonyms:Benzo[1,3]dioxol-5-yl-[(3S,4R,5S)-5-benzo[1,3]dioxol-5-yl-4-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-methanone

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Chemical Property of Benzo[1,3]dioxol-5-yl-[(3S,4R,5S)-5-benzo[1,3]dioxol-5-yl-4-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-methanone

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Technology Process of Benzo[1,3]dioxol-5-yl-[(3S,4R,5S)-5-benzo[1,3]dioxol-5-yl-4-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-methanone

There total 13 articles about Benzo[1,3]dioxol-5-yl-[(3S,4R,5S)-5-benzo[1,3]dioxol-5-yl-4-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 195321-38-1
C₄₃H₅₄O₈Si₂

: (7S,8S)-8-Benzo[1,3]dioxol-5-yl-7-(tert-butyl-diphenyl-silanyloxymethyl)-7,8-dihydro-6H-naphtho[2,3-d][1,3]dioxol-5-one

: 195321-33-6
Benzo[1,3]dioxol-5-yl-[(3S,4R,5S)-5-benzo[1,3]dioxol-5-yl-4-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-methanone

Guidance literature:: With titanium tetrachloride; In dichloromethane; at -78 ℃; for 2.5h;
DOI:10.1021/jo971027c

Reference yield: 6.0%

: C₄₃H₅₄O₈Si₂

: (7S,8S)-8-Benzo[1,3]dioxol-5-yl-7-(tert-butyl-diphenyl-silanyloxymethyl)-7,8-dihydro-6H-naphtho[2,3-d][1,3]dioxol-5-one

: 195321-33-6
Benzo[1,3]dioxol-5-yl-[(3S,4R,5S)-5-benzo[1,3]dioxol-5-yl-4-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-methanone

Guidance literature:: With titanium tetrachloride; In dichloromethane; at -78 ℃; for 2.5h;
DOI:10.1021/jo971027c

Reference yield:

: 2635-13-4
1,2-(methylenedioxy)-4-bromobenzene

: 195321-33-6
Benzo[1,3]dioxol-5-yl-[(3S,4R,5S)-5-benzo[1,3]dioxol-5-yl-4-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) t-BuLi / 1) THF, pentane, -78 deg C, 20 min; 2) THF, pentane, -78 deg C, 1 h, -78 deg C --> rt, 2.5 h

2: 90 percent / MnO₂ / CH₂Cl₂ / 19 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 2.5 h / Ambient temperature

4: 63 percent / TiCl₄ / CH₂Cl₂ / 2.5 h / -78 °C

With manganese(IV) oxide; tert.-butyl lithium; titanium tetrachloride; triethylamine; In dichloromethane;
DOI:10.1021/jo971027c